MP08-14 LONG TERM OUTCOMES OF REPEATED MITOMYCIN C INSTILLATION IN LOW RISK AND INTERMEDIATE RISK NON-MUSCLE INVASIVE BLADDER CANCER PATIENTS

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP08-14 LONG TERM OUTCOMES OF REPEATED MITOMYCIN C INSTILLATION IN LOW RISK AND INTERMEDIATE RISK NON-MUSCLE INVASIVE BLADDER CANCER PATIENTS Pietro Scilipoti, Mattia Longoni, Mario de Angelis, Chiara Re, Giuseppe Rosiello, Alessandro Bertini, Giulio Avesani, Donato Cannoletta, Giorgio Gandaglia, Umberto Capitanio, Andrea Salonia, Francesco Montorsi, Alberto Briganti, and Marco Moschini Pietro ScilipotiPietro Scilipoti More articles by this author , Mattia LongoniMattia Longoni More articles by this author , Mario de AngelisMario de Angelis More articles by this author , Chiara ReChiara Re More articles by this author , Giuseppe RosielloGiuseppe Rosiello More articles by this author , Alessandro BertiniAlessandro Bertini More articles by this author , Giulio AvesaniGiulio Avesani More articles by this author , Donato CannolettaDonato Cannoletta More articles by this author , Giorgio GandagliaGiorgio Gandaglia More articles by this author , Umberto CapitanioUmberto Capitanio More articles by this author , Andrea SaloniaAndrea Salonia More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , and Marco MoschiniMarco Moschini More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003223.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The use of repeated Mitomycin C (MMC) instillation in low- (LR) and intermediate-risk (IR) Non-Muscle Invasive Bladder Cancer (NMIBC) is still a matter of discussion among the urological community. The aim of the current study was to analyze long term outcomes of maintenance regimen of repeated MMC instillations in LR and IR patients. METHODS: We identified 228 patients diagnosed with NMBIC after transurethral resection of bladder tumor (TURBT) that underwent MMC instillations between 2013 and 2022 at a tertiary referral center. All patients felt within the criteria for LR or IR class according to European Association of Urology Guidelines. Recurrence-free survival (RFS) was analyzed and compared with Cox-derived univariate Kaplan-Meier (KM). A Multivariable Cox-regression analyses (MVA) assessed the impact of MMC maintenance regimen on RFS (covariates: T stage, grade, multifocality, early instillation). Subgroup analysis evaluated the effect of MMC instillations number on RFS in patients who received maintenance. RESULTS: Overall, 89 (39%) and 139 (61%) patients were diagnosed with LR and IR NMIBC, respectively. Low grade lesions were found in 88% (n=200) of cases. Pathological Ta tumors were 93% (n=211) and multifocality was present in 107 cases (47%). Median age at diagnosis and follow-up time were 71 (IQR 62-77) and 44 months (IQR 28-63), respectively. Early instillation was performed in only 21 patients (9.2%). Recurrence occurred in 57 patients (25%). All patients underwent MMC induction with 89% rate of 6-instillations cycle completion; 118 patients (51%) underwent maintenance instillations with a median number of instillations equal to 9.5 (6-11). Overall, RFS at 5 years follow-up was 69.6% [62.7, 77.2]. Patients who did or did not receive MMC maintenance had a 5-years RFS of 73.4% vs 65.2%. At MVA, MMC maintenance and number of instillations did not significantly correlate with a better RFS. CONCLUSIONS: Our study showed that MMC maintenance instillations do not reduce the risk of recurrence in LR and IR NIMBC patients who received MMC induction. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e99 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Pietro Scilipoti More articles by this author Mattia Longoni More articles by this author Mario de Angelis More articles by this author Chiara Re More articles by this author Giuseppe Rosiello More articles by this author Alessandro Bertini More articles by this author Giulio Avesani More articles by this author Donato Cannoletta More articles by this author Giorgio Gandaglia More articles by this author Umberto Capitanio More articles by this author Andrea Salonia More articles by this author Francesco Montorsi More articles by this author Alberto Briganti More articles by this author Marco Moschini More articles by this author Expand All Advertisement PDF downloadLoading ...