MP08-11 BODY COMPOSITION CAN PREDICT ONCOLOGICAL OUTCOME IN NON-MUSCLE INVASIVE BLADDER CANCER PATIENTS WHO RECEIVE INTRAVESICAL INSTILLATION WITH BACILLUS CALMETTE-GUERIN AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP08-11 BODY COMPOSITION CAN PREDICT ONCOLOGICAL OUTCOME IN NON-MUSCLE INVASIVE BLADDER CANCER PATIENTS WHO RECEIVE INTRAVESICAL INSTILLATION WITH BACILLUS CALMETTE-GUERIN AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR Fan-Ting Liao, Liang-Kang Huang, Chun-Te Wu, Cheng-Keng Chuang, See-Tong Pang, Kai-Jie Yu, Po-Hung Lin, I-Hung Shao, Hung-Cheng Kan, Yuan-Cheng Chu, Ying-Hsu Chang, and Li-Jen Wang Fan-Ting LiaoFan-Ting Liao More articles by this author , Liang-Kang HuangLiang-Kang Huang More articles by this author , Chun-Te WuChun-Te Wu More articles by this author , Cheng-Keng ChuangCheng-Keng Chuang More articles by this author , See-Tong PangSee-Tong Pang More articles by this author , Kai-Jie YuKai-Jie Yu More articles by this author , Po-Hung LinPo-Hung Lin More articles by this author , I-Hung ShaoI-Hung Shao More articles by this author , Hung-Cheng KanHung-Cheng Kan More articles by this author , Yuan-Cheng ChuYuan-Cheng Chu More articles by this author , Ying-Hsu ChangYing-Hsu Chang More articles by this author , and Li-Jen WangLi-Jen Wang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003223.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Review of previous literature showed still conflicted opinions on influence of obesity in bladder cancer (BC) prognosis, while high body mass index(BMI) being an independent risk factor of BC. This study was aimed to find out the impact of body composition, including sarcopenia and obesity, on the oncological prognosis of non-muscle invasive bladder cancer (NMIBC) patients receiving transurethral resection of bladder tumor (TURBT) with adjuvant intravesical instillation (IVI) with Bacillus Calmette-Guerin (BCG). METHODS: We retrospectively recruited patients with NMIBC who had received TURBT with adjuvant IVI with BCG from March 2005 to April 2021. Body composition parameters were evaluated according to analysis of computed tomography (CT) L3 images with artificial intelligence (AI) models and BMI, and was further categorized into sarcopenia and obesity groups. Oncological outcomes including recurrence-free survival (RFS), progression-free survival (PFS) and overall survival (OS) after treatment of TURBT with adjuvant IVI with BCG were analyzed using uni- and multivariate analysis. Impact of sarcopenia and obesity was analyzed with Kaplan-Meier survival exam. RESULTS: Total of 269 patients were enrolled. All patients were diagnosed with NMIBC and majority were Ta or T1, accounting for 44.6% and 50.9% respectively. Among them, 80 patients were sarcopenic and 53 were obese, accounting for 29.7% and 19.7% respectively. Subcutaneous adipose tissue density on CT was a significant predictor for RFS (p=0.011) and psoas muscle density also had significant impact on OS (p=0.044) in multivariate analysis. Sarcopenic or non-obese patients endured significantly fewer BCG IVI than non-sarcopenic or obese patients. Patients with sarcopenia had poorer RFS (p=0.030) and OS (p=0.033). In contrast, obese patients had better OS (p=0.008). CONCLUSIONS: In our study, we first demonstrated that body composition, sarcopenia, and obesity had significant impact on the RFS, PFS and OS in NMIBC patients. Non-sarcopenic and obese patients can significantly endure more BCG IVI and thus may result in superior oncological outcome. In patients with NMIBC, obese group had better OS while sarcopenic patients had worse OS and RFS. Body composition measurements has potentials in assessments of oncological outcomes of NMIBC patients. Source of Funding: No source of funding © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e98 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Fan-Ting Liao More articles by this author Liang-Kang Huang More articles by this author Chun-Te Wu More articles by this author Cheng-Keng Chuang More articles by this author See-Tong Pang More articles by this author Kai-Jie Yu More articles by this author Po-Hung Lin More articles by this author I-Hung Shao More articles by this author Hung-Cheng Kan More articles by this author Yuan-Cheng Chu More articles by this author Ying-Hsu Chang More articles by this author Li-Jen Wang More articles by this author Expand All Advertisement PDF downloadLoading ...