MP08-10 LATERALIZATION OF BLADDER FUNCTION IN NORMAL FEMALE CANINES

Abstract

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology (MP08)1 Sep 2021MP08-10 LATERALIZATION OF BLADDER FUNCTION IN NORMAL FEMALE CANINES Dania Giaddui, Mary F. Barbe, Ekta Tiwari, Alan S. Braverman, Danielle S. Porreca, Sandra Gomez-Amaya, Nagat Frara, Lucas J. Hobson, Justin M. Brown, Michael A. Pontari, and Michael R. Ruggieri Dania GiadduiDania Giaddui More articles by this author , Mary F. BarbeMary F. Barbe More articles by this author , Ekta TiwariEkta Tiwari More articles by this author , Alan S. BravermanAlan S. Braverman More articles by this author , Danielle S. PorrecaDanielle S. Porreca More articles by this author , Sandra Gomez-AmayaSandra Gomez-Amaya More articles by this author , Nagat FraraNagat Frara More articles by this author , Lucas J. HobsonLucas J. Hobson More articles by this author , Justin M. BrownJustin M. Brown More articles by this author , Michael A. PontariMichael A. Pontari More articles by this author , and Michael R. RuggieriMichael R. Ruggieri More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001981.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Many organs in the body have either left or right dominance in their innervation. Since the bladder receives innervation from the right and left sides through the spinal cord and the pelvic plexus, this study aimed to examine if stimulations of either the spinal roots or pelvic nerve cause a greater bladder contraction on the left versus the right side. METHODS: Forty-four female canines were included in this study. Functional electrical stimulation (3-5 second trains at 20Hz, 0.02 msec, 0.5-10 mA) of bilateral lumbar (L)6 through sacral (S)3 spinal cord roots and the left and right pelvic plexuses were performed for all animals. Changes in detrusor pressure were continuously recorded during stimulations. Strength of nerve-evoked bladder contractions after spinal root and pelvic plexus stimulations were derived from differences between the resting baseline pressure and the peak pressure obtained during the stimulation. The dominant side for each spinal root and pelvic nerve in each animal was determined by calculating the percent difference (25%) between the left and right stimulation. Bladders are considered left or right sided if differences are greater or less than 25%, respectively. If differences are within 25%, bladders are considered bilaterally innervated. RESULTS: The functional bilateral spinal root stimulation in 2/3 of the 44 dogs examined indicated that the maximum detrusor pressure was shown to be associated with either the left or right side of the spinal cord that was stimulated. Bladders were left side dominant in seventeen dogs (38.6%), right side dominant in 12 dogs (27.2%) and bilateral in 15 dogs (34%). Functional electrical stimulation of pelvic nerve revealed that about 3/4 of the 19 dogs tested, changes in detrusor pressure was shown to be associated with the side that was stimulated. Bladders were left side dominant in 8 dogs (42.1%), right side dominant in 6 dogs (31.6%) and bilateral in the remaining 5 dogs (26.3%). CONCLUSIONS: Overall, these data provide evidence for asymmetry of the bladder function in the normal female dogs. Although, the current observations were obtained from normal animals, the determined left and right dominance of the bladder function might provide the basis for understanding the consequences of lateralization of bladder innervation in patients with bladder dysfunctions. Source of Funding: NINDS R01NS070267 © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e153-e154 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dania Giaddui More articles by this author Mary F. Barbe More articles by this author Ekta Tiwari More articles by this author Alan S. Braverman More articles by this author Danielle S. Porreca More articles by this author Sandra Gomez-Amaya More articles by this author Nagat Frara More articles by this author Lucas J. Hobson More articles by this author Justin M. Brown More articles by this author Michael A. Pontari More articles by this author Michael R. Ruggieri More articles by this author Expand All Advertisement Loading ...