MP08-04 USE OF PRE-OPERATIVE TESTOSTERONE PRIOR TO DISTAL HYPOSPADIAS REPAIR DOES NOT INCREASE POST-OPERATIVE COMPLICATIONS

Abstract

You have accessJournal of UrologyCME1 May 2022MP08-04 USE OF PRE-OPERATIVE TESTOSTERONE PRIOR TO DISTAL HYPOSPADIAS REPAIR DOES NOT INCREASE POST-OPERATIVE COMPLICATIONS Sahar Eftekharzadeh, Sameer Mittal, Nathan Hyacinthe, Dana A. Weiss, Jason Van Batavia, Aseem R. Shukla, Arun K. Srinivasan, Thomas F. Kolon, Stephen A. Zderic, Douglas A. Canning, Mark R. Zaontz, and Christopher J. Long Sahar EftekharzadehSahar Eftekharzadeh More articles by this author , Sameer MittalSameer Mittal More articles by this author , Nathan HyacintheNathan Hyacinthe More articles by this author , Dana A. WeissDana A. Weiss More articles by this author , Jason Van BataviaJason Van Batavia More articles by this author , Aseem R. ShuklaAseem R. Shukla More articles by this author , Arun K. SrinivasanArun K. Srinivasan More articles by this author , Thomas F. KolonThomas F. Kolon More articles by this author , Stephen A. ZdericStephen A. Zderic More articles by this author , Douglas A. CanningDouglas A. Canning More articles by this author , Mark R. ZaontzMark R. Zaontz More articles by this author , and Christopher J. LongChristopher J. Long More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002530.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Pre-operative Testosterone (T) administration prior to hypospadias repair with the goal of improving surgical outcomes is a common practice among pediatric urologists, however, there is some literature suggesting an increase in complications. We hypothesized that T administration prior to repair of distal hypospadias would not result in higher rates of complications or unplanned encounters. METHODS: A single-institution prospective database of hypospadias patients was queried to identify primary single-stage distal hypospadias repairs from 2016 to 2021. Patients with known T administration status and documented intraoperative measurement of glans width (GW) were included.Our primary goal was to compare complication rates, unfavorable cosmetic outcomes (i.e. redundant skin, skin bridge, etc.), unplanned encounters (i.e. unplanned office visits, ED visits and readmissions), and reoperation rates between patients who received T vs those who did not. Multivariable logistic regression analysis was used to determine role of T administration in incidence of unfavorable outcomes, unplanned encounters, and reoperation. RESULTS: Of 1545 hypospadias repairs, 542 (35%) patients with a median age of 0.7 years (IQR: 0.6, 1.0) at surgery and a median follow-up of 18 months (IQR: 6, 32) were included in this study. 176/542 (33%) patients received T prior to surgery [Table]. There was no significant difference in surgical outcomes, cosmetic outcomes, unplanned encounters, and 30-day complications between the two groups. Multivariate analysis demonstrated that when controlled for race, ethnicity, and age at surgery, incidence of unplanned encounters and unfavorable outcomes were not affected by administration of T (p>0.05). Additionally, Multivariate analysis showed that Black and African-American patients were at higher risk for unplanned encounters compared to others (OR: 3.3, 95%CI: 1.4 - 7.6, p<0.01). CONCLUSIONS: Pre-operative T administration results in a significant increase in penile glans width. For single-stage repair of distal hypospadias, T is safe and does not increase the rate of surgical complication development. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e126 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sahar Eftekharzadeh More articles by this author Sameer Mittal More articles by this author Nathan Hyacinthe More articles by this author Dana A. Weiss More articles by this author Jason Van Batavia More articles by this author Aseem R. Shukla More articles by this author Arun K. Srinivasan More articles by this author Thomas F. Kolon More articles by this author Stephen A. Zderic More articles by this author Douglas A. Canning More articles by this author Mark R. Zaontz More articles by this author Christopher J. Long More articles by this author Expand All Advertisement PDF DownloadLoading ...