Abstract
Roux-en-Y gastric bypass (RYGB) surgery is the most common surgical intervention for long-term weight loss in morbidly obese patients. As popularity and demand for this therapy has expanded, renal manifestations such as oxalate nephropathy and nephrolithiasis appear to be increasing in this patient population. With the intention to develop a murine model of bariatric surgery induced calcium oxalate nephrolithiasis, we performed RYGB in obese rats on a high fat, normal oxalate diet and tested whether the RYGB surgery causes detrimental renal injury and mineral deposition.
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