MP07-03 ANASTRAZOLE IS AN EFFECTIVE TREATMENT FOR INFERTILE MEN WITH HYPERESTROGENEMIA

Abstract

You have accessJournal of UrologyInfertility: Therapy II1 Apr 2018MP07-03 ANASTRAZOLE IS AN EFFECTIVE TREATMENT FOR INFERTILE MEN WITH HYPERESTROGENEMIA Andrew Radtke, Dane Johnson, Luriel Smith-Harrison, and Jay Sandlow Andrew RadtkeAndrew Radtke More articles by this author , Dane JohnsonDane Johnson More articles by this author , Luriel Smith-HarrisonLuriel Smith-Harrison More articles by this author , and Jay SandlowJay Sandlow More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.3066AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Male infertility has multiple etiologies, many of which are treatable. Recent reports have demonstrated the deleterious impact of obesity on male fertility. Obese men often experience hypogonadism, typically secondary to hyperestrogenemia. This is presumably due to increased aromatase activity in body fat, resulting in impaired hormone and sperm production. The aim of this study is to investigate the effect of anastrazole on semen profiles in infertile men with hyperestrogenemia. METHODS Following IRB approval, we retrospectively evaluated all patients seen at a single academic Reproductive Medicine Center from January 2011 to June 2016 for infertility related to hyperestrogenemia. Patients included in this study demonstrated either true (Estradiol >42pg/mL) or relative (defined as Testosterone: Estradiol ratios <10) hyperestrogenemia, with at least 1 abnormal semen analysis, and subsequently underwent treatment with anastrazole 1 mg 3 times/week. Any patients with palpable varicoceles, hypergonadotrophic hypogonadism, or those receiving any additional hormonally active pharmaceuticals were excluded. Patient characteristics included testicular volume, BMI, as well as their hormonal evaluation, which included serum Follicle-Stimulating Hormone (FSH), Luteinizing Hormone (LH), total Testosterone (T) and Estradiol (E2) levels. Semen parameters were compared pre-and post-treatment. RESULTS Seventy-two patients fit inclusion criteria and received anastrazole for either true or relative hyperestrogenemia. 23 patients had adequate post treatment follow up for evaluation. Following initiation of anastrazole therapy, average T, T:E2 ratios, total sperm count, and total progressively motile sperm count all significantly increased. Thirteen patients (56%) experienced a >50% increase in total progressively motile sperm counts (p=0.02). CONCLUSIONS Anastrazole therapy can significantly improve semen quality in infertile men with hyperestrogenemia. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e88 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Andrew Radtke More articles by this author Dane Johnson More articles by this author Luriel Smith-Harrison More articles by this author Jay Sandlow More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...