MP05-19 THE FACTORS ASSOCIATED WITH GLEASON UPGRADING AT RADICAL PROSTATECTOMY: A PERSPECTIVE FROM THE SINGLE INSTITUTIONAL ASSESSMENT OF BIOPSY AND FINAL PATHOLOGY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy I1 Apr 2018MP05-19 THE FACTORS ASSOCIATED WITH GLEASON UPGRADING AT RADICAL PROSTATECTOMY: A PERSPECTIVE FROM THE SINGLE INSTITUTIONAL ASSESSMENT OF BIOPSY AND FINAL PATHOLOGY Selcuk Erdem, Samed Verep, Tzevat Tefik, Yasemin Ozluk, Isin Kilicaslan, Murat Tunc, Oner Sanli, Ismet Nane, and Faruk Ozcan Selcuk ErdemSelcuk Erdem More articles by this author , Samed VerepSamed Verep More articles by this author , Tzevat TefikTzevat Tefik More articles by this author , Yasemin OzlukYasemin Ozluk More articles by this author , Isin KilicaslanIsin Kilicaslan More articles by this author , Murat TuncMurat Tunc More articles by this author , Oner SanliOner Sanli More articles by this author , Ismet NaneIsmet Nane More articles by this author , and Faruk OzcanFaruk Ozcan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.190AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Gleason upgrading (GU) at radical prostatectomy (RP) is a concern in the prostate cancer (PCa) treatment. This study aims to investigate which clinical and histopathologic factors are associated to GU at RP. METHODS Between January 2005-September 2017, 694 RPs were performed in our department. After excluding 21 RPs with incomplete records, 673 RPs were included in this study and divided into two groups: Group 1 (Upgrading) and Group 2 (No Upgrading). A subgroup of 443 patients whose biopsy were examined by only our institutional pathology department were divided by same grouping. The retrospectively collected clinical and histopathological parameters were compared between two groups. Chi square and Mann-Whitney U tests were used to compare categorical and non-parametric continuous parameters, respectively. Logistic regression was used for multivariate analysis. RESULTS The analyses of overall and subgroup cohorts found that PSA level (p=0.001, p=0.005) and pathologic tumor size (p<0.001, p<0.001) were increased while pathologic prostate weight (p=0.001, p=0.006) was decreased in Group 1. The biopsy report from external institution (p<0.001) was higher in Group 1 at the comparison of overall cohort. The rates of pT3 stage (p<0.001, p<0.001), extraprostatic disease (p<0.001, p=0.001), perineural invasion (p<0.001, p<0.001), apical (p=0.001, p=0.001) and bladder neck (p=0.017, p=0.007) involvement were higher in Group 1 at two comparisons. Multivariate analyses showed that the independent factors associated with GU after RP were perineural invasion (p<0.001), biopsy report of external institution (p<0.001) and pathologic tumor size (p=0.001) at overall cohort meanwhile perineural invasion (p=0.001), pathologic tumor size (p=0.034) and apical involvement (p=0.044) at subgroup cohort. CONCLUSIONS Single institutional assessment of bioptic and final pathologies may reduce GU reports at RP. However it plays a marginal role to define independent factors associated with GU. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e50-e51 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Selcuk Erdem More articles by this author Samed Verep More articles by this author Tzevat Tefik More articles by this author Yasemin Ozluk More articles by this author Isin Kilicaslan More articles by this author Murat Tunc More articles by this author Oner Sanli More articles by this author Ismet Nane More articles by this author Faruk Ozcan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...