MP05-17 RISKS OF CAROTID ARTERY STENOSIS AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN PATIENTS WITH CALCIUM KIDNEY STONE: ASSESSMENT OF SYSTEMIC INFLAMMATORY BIOMARKERS

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP05-17 RISKS OF CAROTID ARTERY STENOSIS AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE IN PATIENTS WITH CALCIUM KIDNEY STONE: ASSESSMENT OF SYSTEMIC INFLAMMATORY BIOMARKERS Chang Te Wang, Chan Jung Liu, Hau Chern Jan, and Ho Shiang Huang Chang Te WangChang Te Wang More articles by this author , Chan Jung LiuChan Jung Liu More articles by this author , Hau Chern JanHau Chern Jan More articles by this author , and Ho Shiang HuangHo Shiang Huang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003216.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To assess the clinical significance of preoperative inflammatory biomarkers combined with atherosclerotic cardiovascular disease (ASCVD) risk score to evaluate carotid artery stenosis in patients with calcium kidney stones. METHODS: We conducted a prospective observational case-control study, enrolling seventy four patients with calcium kidney stones and sixty six age- and sex-matched healthy controls. We calculated the inflammatory biomarkers including the neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI). Ultrasound of the carotid arteries was performed on all participants to identify the severity of the stenosis. RESULTS: All inflammatory biomarkers and the severity of carotid artery stenosis were higher in the calcium kidney stone group than in controls. After stratification of ASCVD, inflammatory biomarkers and carotid artery stenosis severity were still significantly higher in the calcium kidney stone group. Multivariate analyses showed that calcium kidney stones significantly increased the risk of ASCVD and carotid artery stenosis. In multivariate linear logistic regression analyses, calcium kidney stone and ASCVD score had a significant association with carotid artery occlusion, but SIRI did not. CONCLUSIONS: Calcium kidney stone is associated with higher levels of inflammatory biomarkers and carotid artery stenosis. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e50 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chang Te Wang More articles by this author Chan Jung Liu More articles by this author Hau Chern Jan More articles by this author Ho Shiang Huang More articles by this author Expand All Advertisement PDF downloadLoading ...