MP04-10 RISK OF ORGASMIC FUNCTION IMPAIRMENT AFTER HOLEP – FINDINGS OF A PROSPECTIVE REAL-LIFE TRIAL (EXPHO)

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You have accessJournal of UrologyCME1 May 2022MP04-10 RISK OF ORGASMIC FUNCTION IMPAIRMENT AFTER HOLEP – FINDINGS OF A PROSPECTIVE REAL-LIFE TRIAL (EXPHO) Paolo Capogrosso, Eugenio Ventimiglia, Giuseppe Fallara, Antonio Costa, Francesco Pellegrino, Luigi Candela, Edoardo Pozzi, Federico Belladelli, Mario De Angelis, Gianmarco Colandrea, Walter Cazzaniga, Daniele Cignoli, Nicolò Schifano, Rayan Matloob, Federico Dehò, Vincenzo Scattoni, Andrea Salonia, and Francesco Montorsi Paolo CapogrossoPaolo Capogrosso More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Giuseppe FallaraGiuseppe Fallara More articles by this author , Antonio CostaAntonio Costa More articles by this author , Francesco PellegrinoFrancesco Pellegrino More articles by this author , Luigi CandelaLuigi Candela More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Federico BelladelliFederico Belladelli More articles by this author , Mario De AngelisMario De Angelis More articles by this author , Gianmarco ColandreaGianmarco Colandrea More articles by this author , Walter CazzanigaWalter Cazzaniga More articles by this author , Daniele CignoliDaniele Cignoli More articles by this author , Nicolò SchifanoNicolò Schifano More articles by this author , Rayan MatloobRayan Matloob More articles by this author , Federico DehòFederico Dehò More articles by this author , Vincenzo ScattoniVincenzo Scattoni More articles by this author , Andrea SaloniaAndrea Salonia More articles by this author , and Francesco MontorsiFrancesco Montorsi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002521.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Laser enucleation of the prostate is associated with an invariable risk of retrograde ejaculation which may affect patient’ sexual life with a negative impact toward orgasmic function (OF). We investigated OF outcomes after Holmium Laser Enucleation of the Prostate (HoLEP) in patients consecutively treated at a single center. METHODS: The ExpHo trial (NCT03583034) is a prospective observational study collecting data of patients submitted to HoLEP at a single center. Surgeries were performed by a single highly experienced surgeon. Before surgery, all patients completed the International Index of Erectile Function (IIEF) thus including the OF domain. Non-sexually active patients were excluded. Patients were re-assessed at 1 week, 1-, 3-, 6- and 12-mos. Kaplan-Meier analyses estimated OF recovery over time (defined as: IIEF-OF score ≥than baseline). Logistic regression model tested baseline characteristics associated with the risk of postoperative OF worsening. RESULTS: Data were available for 135 patients. Median (IQR) age was 66 (62,73) years. Median prostate volume (PV) 81 cc (63,110). Overall, 46 (64%) patients had IIEF scores suggestive for ED before surgery. Median IIEF-OF score at baseline was 6 (0,10). Overall, 34% (46) reported a decreased OF after surgery. Mean IIEF-OF score significantly decreased at 1-mo follow-up compared to baseline (6.1 vs. 3.; p <0.0001), with a subsequent improvement at 3-mo (IIEF-OF: 5.4) and 6-mo (IIEF-EF: 5.9), respectively. The estimated (95%CI) postoperative OF recovery rates were 44% (35,54), 62% (53,72), and 77% (66,86) at 1-,3- and 12-mos follow-up. Younger patients (OR: 0.91, 95%CI:0.8-0.9; p=0.03) and patients with normal preoperative IIEF-EF (OR:3.4,95%CI1.1,11.5; p=0.04) emerged to have higher risk of reporting a postoperative decreased IIEF-OF (Figure 1). CONCLUSIONS: One out three patients reported a decrease in OF after HoLEP. Younger patients with normal baseline EF should be carefully counselled regarding the risk of retrograde ejaculation associated with laser enucleation of the prostate. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e61 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Paolo Capogrosso More articles by this author Eugenio Ventimiglia More articles by this author Giuseppe Fallara More articles by this author Antonio Costa More articles by this author Francesco Pellegrino More articles by this author Luigi Candela More articles by this author Edoardo Pozzi More articles by this author Federico Belladelli More articles by this author Mario De Angelis More articles by this author Gianmarco Colandrea More articles by this author Walter Cazzaniga More articles by this author Daniele Cignoli More articles by this author Nicolò Schifano More articles by this author Rayan Matloob More articles by this author Federico Dehò More articles by this author Vincenzo Scattoni More articles by this author Andrea Salonia More articles by this author Francesco Montorsi More articles by this author Expand All Advertisement PDF DownloadLoading ...