MP03-05 HOW DOES THE TYPE OF URINARY DIVERSION AFFECT HEALTH RELATED QUALITY OF LIFE (HRQOL) IN THE COURSE OF FOUR YEARS AFTER RADICAL CYSTECTOMY? - A PROPENSITY SCORE-MATCHED ANALYSIS

Abstract

You have accessJournal of UrologyCME1 May 2022MP03-05 HOW DOES THE TYPE OF URINARY DIVERSION AFFECT HEALTH RELATED QUALITY OF LIFE (HRQOL) IN THE COURSE OF FOUR YEARS AFTER RADICAL CYSTECTOMY? - A PROPENSITY SCORE-MATCHED ANALYSIS Yannic Volz, Lennert Eismann, Benedikt Ebner, Paulo Pfitzinger, Jan-Friedrich Jokisch, Gerald Schulz, Thilo Westhofen, Alexander Karl, Boris Schlenker, Christian Stief, and Alexander Kretschmer Yannic VolzYannic Volz More articles by this author , Lennert EismannLennert Eismann More articles by this author , Benedikt EbnerBenedikt Ebner More articles by this author , Paulo PfitzingerPaulo Pfitzinger More articles by this author , Jan-Friedrich JokischJan-Friedrich Jokisch More articles by this author , Gerald SchulzGerald Schulz More articles by this author , Thilo WesthofenThilo Westhofen More articles by this author , Alexander KarlAlexander Karl More articles by this author , Boris SchlenkerBoris Schlenker More articles by this author , Christian StiefChristian Stief More articles by this author , and Alexander KretschmerAlexander Kretschmer More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002515.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Radical cystectomy (RC) and urinary diversion by ileal conduit (IC) or ileal orthotopic neobladder (ONB) is the standard-of-care for surgical treatment of muscle-invasive bladder cancer. Yet, it remains unclear how the patient’s health-related quality of life (HRQOL) is affected by the choice of urinary diversion in long-term. The current study tries to provide further insight on the quality of life up to four years after RC. METHODS: HRQOL was assessed preoperatively, 3mo postoperatively and annually until a maximum follow-up of 48mo using the validated EORTC QLQ-C30- as well as the bladder cancer-specific FACT-BL- and QLQ-BLM30-questionnaires. The variables “age”, “ASA classification” and “cardiovascular co-morbidity” were used for a propensity-score matching. Potential predictors for decreased general HRQOL were assessed using multivariable logistic regression models. RESULTS: After propensity-score matching, patient cohorts were well-balanced and a total of 260 patients were included. We were able to reveal significant differences regarding preoperative QLQ-C30 symptoms and functioning scores between IC and ONB patients which diminished during the postoperative time course. Similarly, we did not observe significant differences based on bladder cancer-specific FACT-BL and QLQ-BLM HRQOL assessment including body image [48mo: 28.4 (IC) vs. 43.7 (ONB); p=0.439). General HRQOL may increase as we found increased global health status scores for ONB throughout the whole observational period without reaching statistical significance [48mo: 57.1 (IC) vs. 67.7 (ONB); p=0.200]. In multivariate analysis, cardiovascular co-morbidity was an independent predictor of impaired HRQOL 24mo (HR 2.45; CI95% 1.16-5.17, p=0.019) and 36mo (HR 4.84; CI95% 1.39-16.92, p=0.013) postoperatively. CONCLUSIONS: Up to four years after RC we did not observe significant differences between both types of urinary diversion in bladder cancer-specific subscores as well as generic HRQOL. Consequently, the type of urinary diversion was not an independent predictor of good general HRQOL. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e21 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yannic Volz More articles by this author Lennert Eismann More articles by this author Benedikt Ebner More articles by this author Paulo Pfitzinger More articles by this author Jan-Friedrich Jokisch More articles by this author Gerald Schulz More articles by this author Thilo Westhofen More articles by this author Alexander Karl More articles by this author Boris Schlenker More articles by this author Christian Stief More articles by this author Alexander Kretschmer More articles by this author Expand All Advertisement PDF DownloadLoading ...