MP03-16 PHENOTYPING OVERACTIVE BLADDER PATIENTS: MAY MOLECULAR CHARACTERIZATION WITH URINARY BIOMARKERS BE OF HELP?

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You have accessJournal of UrologyCME1 Apr 2023MP03-16 PHENOTYPING OVERACTIVE BLADDER PATIENTS: MAY MOLECULAR CHARACTERIZATION WITH URINARY BIOMARKERS BE OF HELP? Benoit Peyronnet, Claire Richard, Claude Bendavid, Juliette Hascoet, Camille Haudebert, Caroline Voiry, Emmanuelle Samson, Jacques Kerdraon, Andrea Manunta, Jean-Nicolas Cornu, and Xavier Gamé Benoit PeyronnetBenoit Peyronnet More articles by this author , Claire RichardClaire Richard More articles by this author , Claude BendavidClaude Bendavid More articles by this author , Juliette HascoetJuliette Hascoet More articles by this author , Camille HaudebertCamille Haudebert More articles by this author , Caroline VoiryCaroline Voiry More articles by this author , Emmanuelle SamsonEmmanuelle Samson More articles by this author , Jacques KerdraonJacques Kerdraon More articles by this author , Andrea ManuntaAndrea Manunta More articles by this author , Jean-Nicolas CornuJean-Nicolas Cornu More articles by this author , and Xavier GaméXavier Gamé More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003214.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The objective of this study was to evaluate the association between the level of 5 urinary markers (NGF, BDNF, TIMP-2, TGF-B1, and PGE2) and the characteristics of patients with overactive bladder underpinned by detrusor overactivity (OAB-DO) and their possible association with response to treatment METHODS: A single-center prospective study was conducted between March 2015 and June 2017 including all consecutive patients with OAB referred for urodynamics in whom filling cystometry evidenced detrusor overactivity. At the end of the inclusion period, the urine samples were unfrozen to assess the level of NGF, BDNF, TIMP-2, PGE2, TGF-B1 using dedicated ELISA kits. The association between urinary marker levels and patient characteristics was investigated. RESULTS: Forty-three patients were included all with non-neurogenic OAB underpinned by detrusor overactivity on urodynamics. Patients with affective disorders (anxiety, depression) had significantly higher levels of NGF/Cr (2.04 vs. 0.07 pg/mg creatinine; p=0.006) and significantly lower levels of PGE2/Cr compared to other patients (40.6 vs. 83.4 pg/mg creatinine; p=0.008). There were no other statistically significant associations between urinary markers and patient characteristics. There was also no association between urinary marker levels and response to anticholinergics. In contrast, patients who responded to posterior tibial nerve stimulation (PTNS) had significantly lower BDNF/Cr levels (3.5 vs. 7.6 pg/mg creatinine; p=0.03). CONCLUSIONS: In this study there was a molecular signature in the subgroup of patients with affective disorders with significantly higher NGF and significantly lower PGE2 levels compared to other OAB-DO patients. These results reinforce the hypothesis of an OAB phenotype associated with anxiety/depression with a specific pathophysiology. BDNF/Cr may be predictive of response to PTNS. Source of Funding: none © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e29 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Benoit Peyronnet More articles by this author Claire Richard More articles by this author Claude Bendavid More articles by this author Juliette Hascoet More articles by this author Camille Haudebert More articles by this author Caroline Voiry More articles by this author Emmanuelle Samson More articles by this author Jacques Kerdraon More articles by this author Andrea Manunta More articles by this author Jean-Nicolas Cornu More articles by this author Xavier Gamé More articles by this author Expand All Advertisement PDF downloadLoading ...