MP02-13 EFFECTS OF GENDER AND AGE ON LOWER URINARY TRACT SYMPTOMS (LUTS): INSIGHTS FROM THE STANFORD WSDM OBSERVATIONAL LUTS COHORT

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction I (MP02)1 Sep 2021MP02-13 EFFECTS OF GENDER AND AGE ON LOWER URINARY TRACT SYMPTOMS (LUTS): INSIGHTS FROM THE STANFORD WSDM OBSERVATIONAL LUTS COHORT Chen Shenhar, Petah Tikva Israel, Stefanie van Uem, Abdelrahman S. Abdalla, Ashu Mohammad, Bertha H. Chen, Elizabeth A. Kidd, and Amy D. Dobberfuhl Chen ShenharChen Shenhar More articles by this author , Petah Tikva IsraelPetah Tikva Israel More articles by this author , Stefanie van UemStefanie van Uem More articles by this author , Abdelrahman S. AbdallaAbdelrahman S. Abdalla More articles by this author , Ashu MohammadAshu Mohammad More articles by this author , Bertha H. ChenBertha H. Chen More articles by this author , Elizabeth A. KiddElizabeth A. Kidd More articles by this author , and Amy D. DobberfuhlAmy D. Dobberfuhl More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001963.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To describe how specific items in the AUASI and the ICIQ FLUTS / MLUTS differ based on gender and age, in a patient population seeking care for LUTS. METHODS: Subjects were prospectively enrolled into the Stanford WSDM observational LUTS cohort from a functional urology clinic and answered questionnaires. Data were analyzed in SAS using logistic regression to model effects of gender and age on LUTS and quality of life. RESULTS: A total of 304 patients (178 female, 126 male) were enrolled. Mean age was 58±17 years. 540 clinic visits occurred between May 2019 and November 2020. Response rates were 93% (500/540) for AUASI, and 91% (490/540) for ICIQ. A logistic regression model by gender, adjusted for age (Figure 1), demonstrated a greater number of women with urgency using both instruments (AUASI OR 2.27, 95% CI 1.55-3.33; ICIQ OR 2.25, 95% CI 1.42-3.56). Women reported more voiding symptoms than men, including straining (AUASI OR 1.70, 95% CI 1.10-2.62; ICIQ OR 1.79, 95% CI 1.04-3.06). Incontinence was only represented by the ICIQ, where women reported more incontinence than men (ICIQ stress urinary incontinence (UI) OR 6.14, 95% CI 2.55-14.77; ICIQ unaware UI OR 2.18, 95% CI 1.03-4.62; ICIQ sleep UI OR 1.99, 95% CI 1.02-3.90; ICIQ urge UI OR 1.94, 95% CI 1.16-3.26). After adjusting for gender (Figure 2), nocturia was more likely to occur in older patients captured by the ICIQ (ICIQ nocturia OR 1.13, 95% CI 1.01-1.26). Urgency and urge UI occurred more in older subjects in the ICIQ domain for urgency (ICIQ urgency OR 1.16, 95% CI 1.02-1.32; ICIQ urge UI OR 1.23, 95% CI 1.06-1.43). Younger subjects were more likely to report hesitancy (ICIQ OR 0.74, 95% CI 0.65-0.84) and straining (AUASI OR 0.75, 95% CI 0.67-0.84; ICIQ OR 0.82, 95% CI 0.71-0.94). CONCLUSIONS: The AUASI and the ICIQ FLUTS / MLUTS differ based on sex and age in a patient population seeking care for LUTS. The ICIQ questionnaires capture symptom specific bother and incontinence. Further research is needed to better classify gender and age specific impact on LUTS outcomes not captured by the AUASI. Source of Funding: NIH 1L30DK115056-01, Stanford Women's Health and Sex Differences in Medicine (WSDM) Seed Grant © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e16-e17 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chen Shenhar More articles by this author Petah Tikva Israel More articles by this author Stefanie van Uem More articles by this author Abdelrahman S. Abdalla More articles by this author Ashu Mohammad More articles by this author Bertha H. Chen More articles by this author Elizabeth A. Kidd More articles by this author Amy D. Dobberfuhl More articles by this author Expand All Advertisement Loading ...