MP02-08 MICROALBUMINURIA AS AN INDEPENDENT PREDICTOR OF OVERACTIVE BLADDER SYMPTOM EXACERBATION

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction I (MP02)1 Sep 2021MP02-08 MICROALBUMINURIA AS AN INDEPENDENT PREDICTOR OF OVERACTIVE BLADDER SYMPTOM EXACERBATION Yuta Kojima, Teppei Okamoto, Masataka Ando, Songee Jung, Shingo Hatakeyama, Atsushi Imai, Hayato Yamamoto, Tohru Yoneyama, Kazuyuki Mori, Takahiro Yoneyama, Yasuhiro Hashimoto, and Chikara Ohyama Yuta KojimaYuta Kojima More articles by this author , Teppei OkamotoTeppei Okamoto More articles by this author , Masataka AndoMasataka Ando More articles by this author , Songee JungSongee Jung More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Atsushi ImaiAtsushi Imai More articles by this author , Hayato YamamotoHayato Yamamoto More articles by this author , Tohru YoneyamaTohru Yoneyama More articles by this author , Kazuyuki MoriKazuyuki Mori More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001963.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Although exact etiologies of overactive bladder (OAB) remains unclear, one of the believed theories to describe the disease process involves ischemia, vascular damage, and endothelial dysfunction of the bladder. Microalbuminuria (leakage of small amount of albumin into urine) is deeply related to vascular endothelial dysfunction. We hypothesized that microalbuminuria may have a significant association with OAB symptom exacerbation. We investigated the longitudinal association between microalbuminuria and OAB symptoms in a community-residential population. METHODS: This longitudinal study investigated 561 participants of the Iwaki Health Promotion Project in both 2015 and 2019 in Japan. Microalbuminuria and OAB symptoms were assessed using the urine albuminuria creatinine ratio (ACR) and the overactive bladder symptom score (OABSS), respectively. Urine ACR was defined as high if ≥7.4 mg/gCr. Differences in OABSS between 2015 and 2019 were evaluated as ∆OABSS. Participants were divided into two groups according to DOABSS: high (∆OABSS >1) and control (≤1). We used baseline data acquired in 2015, such as urine ACR, the Pittsburgh Sleep Quality Index (PSQI), and arterial stiffness expressed by brachial-ankle pulse wave velocity (baPWV). Predictive factors of a ∆OABSS >1 were assessed by multivariable logistic regression analysis. RESULTS: This study included 332 women and 229 men. Of those, 86 (34 males and 52 females) were classified into the ∆OABSS >1 group. There were significant group differences in age, renal function, and hemoglobin A1c. Participants in the DOABSS >1 had a higher prevalence of PSQI >5, baPWV ≥1400 sec/cm, and urine ACR ≥7.4 mg/gCr (56% vs. 38%, p=0.003) than those in the control group. Multivariable analysis revealed that PSQI >5 (odds ratio [OR]; 2.63, 95% confidence interval [CI]; 1.47–4.69, p=0.001) and urine ACR ≥7.4 mg/gCr (OR; 1.76, 95% CI; 1.04–2.98, p=0.034) were selected as independent risk factors for ∆OABSS >1, whereas baPWV ≥1400 sec/cm was not selected. CONCLUSIONS: Microalbuminuria represented by urine ACR was an independent predictor of OAB symptom exacerbation; therefore, its predictive value might be stronger than baPWV. Further studies are necessary to reveal the exact mechanism underlying the association between urine ACR and OAB. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e14-e14 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yuta Kojima More articles by this author Teppei Okamoto More articles by this author Masataka Ando More articles by this author Songee Jung More articles by this author Shingo Hatakeyama More articles by this author Atsushi Imai More articles by this author Hayato Yamamoto More articles by this author Tohru Yoneyama More articles by this author Kazuyuki Mori More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement Loading ...