MP02-07 REPEAT PROSTATE BIOPSY PATTERNS IN MEN WITH A SINGLE NEGATIVE PROSTATE BIOPSY: A POPULATION-BASED ANALYSIS

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Practice Patterns, Quality of Life and Shared Decision Making I (MP02)1 Apr 2020MP02-07 REPEAT PROSTATE BIOPSY PATTERNS IN MEN WITH A SINGLE NEGATIVE PROSTATE BIOPSY: A POPULATION-BASED ANALYSIS Rashid Sayyid*, Zachary Klaassen, Christopher Wallis, Martha Terris, Rabii Madi, Shabbir Alibhai, Rinku Sutradhar, David Urbach, and Neil Fleshner Rashid Sayyid*Rashid Sayyid* More articles by this author , Zachary KlaassenZachary Klaassen More articles by this author , Christopher WallisChristopher Wallis More articles by this author , Martha TerrisMartha Terris More articles by this author , Rabii MadiRabii Madi More articles by this author , Shabbir AlibhaiShabbir Alibhai More articles by this author , Rinku SutradharRinku Sutradhar More articles by this author , David UrbachDavid Urbach More articles by this author , and Neil FleshnerNeil Fleshner More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000816.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Transrectal ultrasound guided prostate biopsies (TRUS-BX) have false-negative rates in excess of 30%. Recent population-based studies have shown that following a single negative TRUS-BX, 24% of North American men are eventually diagnosed with prostate cancer. The frequency of repeat biopsies, and thus the frequency of health services/resources utilization and its impact on patients' quality of life, is unknown in this unique cohort of patients. Our objective was thus to determine the repeat biopsy pattern of men with a single negative TRUS-BX. METHODS: This is a population-based study of 95,675 men with a single negative TRUS-BX from Ontario, Canada between April 1994 and March 2015. All patients were older than 40 years at inclusion and had no prior history of prostate cancer. Data from the Ontario Health Insurance Plan, Ontario Cancer Registry, and Registered Persons Database, housed at the Institute of Clinical and Evaluative Sciences was used to determine the short- and long-term repeat biopsy patterns of our cohort. RESULTS: The median age of our cohort was 63.0 years (IQR 57.0-70.0). The median time till the 1st repeat biopsy was 1.8 years (IQR 0.7-3.9). Within the 1st year of a negative TRUS-BX, 11.5% of men underwent a repeat biopsy. This value increased to 18.5%, 30.4%, 38.5%, 41.5%, and 42.5% at two, five, ten, 15, and 20 years following a negative TRUS-BX. Among 67,675 men with five years of follow-up, 19.2% underwent only one further TRUS-BX, 6.5% only two, and 2.2% three or more. Among 33,076 men with 10 years of follow-up, 22.5% underwent one repeat TRUS-BX only, 9.6% two further TRUS-BX only, and 5.7% three or more during that time frame. The highest number of repeat biopsies underwent was 11. CONCLUSIONS: Following a negative TRUS-BX, the median time to a repeat TRUS-BX was 1.8 years, the vast majority of which were within the initial ten years. Within ten years of a negative TRUS-BX, 38.5% of men had undergone at least one further TRUS-BX, with 15.3% of the total undergoing at least two further biopsies. These results will help inform health policy decision makers and allow urologists to educate their patients regarding their likelihood of undergoing further TRUS-BXs following a negative procedure. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e13-e14 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rashid Sayyid* More articles by this author Zachary Klaassen More articles by this author Christopher Wallis More articles by this author Martha Terris More articles by this author Rabii Madi More articles by this author Shabbir Alibhai More articles by this author Rinku Sutradhar More articles by this author David Urbach More articles by this author Neil Fleshner More articles by this author Expand All Advertisement PDF downloadLoading ...