MP-12.04: Low frequency of chromosomal alterations in CGH analysis in low-risk papillary bladder tumors with FGFR3 mutations

K Junker,J Van Oers,E Zwarthoff,I Kania,J Schubert,A Hartmann

doi:10.1016/j.urology.2006.08.409

MP-12.04: Low frequency of chromosomal alterations in CGH analysis in low-risk papillary bladder tumors with FGFR3 mutations

K Junker, J Van Oers + Show 4 more

https://doi.org/10.1016/j.urology.2006.08.409

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Journal: Urology

Publication Date: Oct 17, 2006

Affiliation: Friedrich Schiller University Jena, Erasmus MC, University of Regensburg

#Tumors Of Low Malignant Potential #Tumors Of Different Grade + Show 8 more

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Abstract

It has been suggested that mutation of FGFR3 is associated with non-invasive tumors of low malignant potential and low risk of recurrence and progression. We hypothesize that FGFR3-mutated tumors are more genetically stable than bladder tumors without mutation. The aim of this study was to analyze the distribution of FGFR3 mutations in bladder tumors of different grade and stage and determine the relation of FGFR3 mutations to chromosomal alterations detected by CGH.

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