Moxalactam treatment of uncomplicated gonorrhea in women.

Abstract

The efficacy of a 1-g dose of moxalactam was evaluated in the treatment of uncomplicated gonorrhea in women. Of 100 infected women, 96 had negative cultures after treatment. Two of the four who were not cured may have been reinfected, while therapy appeared to have failed in the other two. The MICs of moxalactam and penicillin were less than 1 microgram/ml for 100% and less than 0.06 micrograms/ml for 90% of the 115 pre- and post-treatment isolates tested. Moxalactam appears to be safe and effective in the treatment of uncomplicated gonorrhea in women. All of four white women and one of seven black women with pharyngeal gonorrhea gave a history of fellatio. Among those without pharyngeal gonorrhea, 20 of 35 white women and 15 of 111 black women gave such a history. Thus, a history of fellatio may not adequately predict which patients are at risk of pharyngeal gonorrhea, especially for black women.