Mowat Wilson Syndrome Presenting as Purpura Fulminans in a Healthy Infant

Abstract

Introduction: Purpura fulminans is a rapidly progressive syndrome of intravascular thrombosis and hemorrhagic infarction of the skin associated with vascular collapse. It is most commonly a complication of Neisseria meningitidis sepsis, and less frequently attributable to Streptococcus pneumoniae. The most common predisposing factor for invasive pneumococcal infection is splenic dysfunction. Case Report: A 10-month old girl with history of gross motor developmental delay presented to an outside hospital with one day of rhinorrhea, tactile fever, drowsiness and poor feeding. She was hypotensive and tachycardic, and had a generalized tonic-clonic seizure and petechial rash that quickly progressed to purpuric. CSF …