Abstract
Life scientists who study carbohydrate structures are all too accustomed to hearing, “So, what are those things good for anyway?” In PNAS, Schjoldager et al. (1) provide an elegant comeback by using a unique strategy for mapping the location of O-GalNAc–linked carbohydrate structures to show how the addition of GalNAc to specific Ser and Thr residues by one of 20 polypeptide GalNAc-transferases (ppGalNAc-Ts) can modulate the biologic activity of the modified glycoprotein. The consequences can be dramatic, for example, altering cholesterol or triglyceride metabolism and thus exerting a significant effect on human health parameters.
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