Year-end Sale % OFF 
Abstract
Patients with Parkinson's disease (PD) often have difficulties generating rhythmic movements, and also difficulties on movement adjustments to accuracy constraints. In the reciprocal aiming task, maintaining a high accuracy comes with the cost of diminished movement speed, whereas increasing movement speed disrupts end-point accuracy, a phenomenon well known as the speed-accuracy trade-off. The aim of this study was to examine how PD impacts speed-accuracy trade-off during rhythmic aiming movements by studying the structural kinematic movement organization and to determine the influence of dopamine replacement therapy on continuous movement speed and accuracy. Eighteen patients with advanced idiopathic Parkinson's disease performed a reciprocal aiming task, where the difficulty of the task was manipulated through target width. All patients were tested in two different sessions: ON-medication and OFF-medication state. A control group composed of healthy age-matched participants was also included in the study. The following variables were used for the analyses: Movement time, Error rate, effective target width, and Performance Index. Percentage of acceleration time and percentage of non-linearity were completed with kinematics patterns description using Rayleigh-Duffing model. Both groups traded off speed against accuracy as the constraints pertaining to the latter increased. The trade-off was more pronounced with the PD patients. Dopamine therapy allowed the PD patients to move faster, but at the cost of movement accuracy. Surprisingly, the structural kinematic organization did not differ across group nor across medication condition. These results suggest that PD patients, when involved in a reciprocal aiming task, are able to produce rhythmic movements. PD patients' overall slowing down seems to reflect a global adaptation to the disease in the absence of a structurally altered kinematic organization.
Highlights
Parkinson’s Disease (PD) is clinically characterized by the parkinsonian triad and patients often have difficulties in generating rhythmic movements [1]
A significant main effect of Group [F [1, 34] = 16.69, p < 0.001, η2 = 0.33] demonstrated that Parkinson’s disease (PD) patients moved slower than control participants
The key findings of this study are that (i) the speed-accuracy trade-off is at work in patients with moderate PD in reciprocal precision aiming extending the findings previously obtained in discrete tasks, (ii) dopaminergic medication leads PD patients to favor speed over accuracy, (iii) the movement organization of rhythmic movements is structurally similar between PD and controls
Summary
Parkinson’s Disease (PD) is clinically characterized by the parkinsonian triad (bradykinesia, rigidity and rest tremor) and patients often have difficulties in generating rhythmic movements [1]. In daily life, this may lead to impairments in various activities such as walking, writing and manipulating objects. This may lead to impairments in various activities such as walking, writing and manipulating objects Such skills, by definition, require movement adjustments to deal with the prevailing accuracy constraints. By definition, require movement adjustments to deal with the prevailing accuracy constraints Succeeding in these tasks comes with the cost of diminished movement speed, whereas increasing movement speed disrupts end-point accuracy.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
