Abstract
The movement of subcellular calcium in the liver was investigated after a single intraperitoneal administration of calcium chloride to bile duct-ligated rats. The hepatic mitochondrial and microsomal calcium levels significantly increased 10 min after the administration of calcium (4.0 and 15.0 mg Ca/100g body weight) to sham-operated rats, and began to decrease 30 and 60 min after that time. However, those reduction were clearly prevented by ligation of the bile duct. The administration of calcium (15.0 mg Ca/100g) to bile duct-ligated rats induced a marked accumulation of calcium in the mitochondria as compared with the microsomes. Meanwhile, the cytosolic calcium was not significantly increased by the administration of calcium (4.0 and 15.0 mg Ca/100 g). The present results suggest that the cytosolic calcium taken up by the liver cells is largely regulated by accumulation into the mitochondria and transportation into the biliary duct of rat liver.
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