Abstract
Mammalian Germ Cells Mammalian mature oocytes, the largest cells in the body, are capable of programming and reprogramming embryogenesis. Only about 20% of developing mouse germ cells become oocytes. Lei and Spradling show that organelles and the cytoplasm move through intercellular connections between sister germ cells in mouse fetal ovaries to enrich oocyte cytoplasm just before oocytes arrest to form the ovarian reserve (see the Perspective by Pepling). Similar transfers occur during oogenesis in many invertebrate and lower vertebrate species, possibly providing oocytes their special properties for programming embryo development. Science , this issue p. [95][1]; see also p. [35][2] [1]: /lookup/doi/10.1126/science.aad2156 [2]: /lookup/doi/10.1126/science.aaf4943
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