Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA[Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development

Bradley A Carlson,Lionel Feigenbaum,Ryuta Tobe,Dolph L Hatfield,Byeong Jae Lee,Salvador Naranjo-Suarez,Min-Hyuk Yoo,Fang Chen,Petra A Tsuji,Vadim N Gladyshev,Lino Tessarollo

doi:10.1007/978-1-4614-1025-6_44

Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA[Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development

Bradley A Carlson, Lionel Feigenbaum + Show 9 more

https://doi.org/10.1007/978-1-4614-1025-6_44

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Publication Date: Jan 1, 2011

Citations: 1

Affiliation: National Cancer Institute, National Institutes of Health, Center for Cancer Research, Science Applications International Corporation (United States), Seoul National University, Brigham and Women's Hospital, Harvard University, Cancer Genetics (United States)

#Selenoproteins In Health #Selenoproteins In Development + Show 8 more

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Abstract

Several mouse models targeting the selenocysteine (Sec) tRNA[Ser]Sec gene for removal or overexpression have been generated and they include: (1) mice carrying a conditional knockout of the Sec tRNA gene; (2) transgenic mice encoding wild type or mutant Sec tRNA transgenes; and (3) conditional knockout/transgenic or standard knockout/transgenic mice carrying wild type or mutant Sec tRNA transgenes. These models have provided powerful tools for elucidating the roles of selenoproteins in development and health.

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