Abstract
Abstract The Jackson Laboratory Repository serves as a centralized facility for the development, rederivation, distribution and cryopreservation of mouse models of human biology and disease. Hundreds of strains are added annually to one of the largest collections of characterized mouse strains available to the biomedical research community. This poster presents new knockout (KO) strains carrying genes associated with T cells and antigen (Ag) presentation. Lcp2 (SLP-76)-null mice lack T cells and γδ-TCR+ cells. Psmb8 (LMP-7) KO mice exhibit impaired Ag presentation and reduced T cells. In Clec9a (DNGR-1) KO/GFP knock-in (KI) mice, cross-priming of CD8+ T cells against dead-cell-associated antigens is altered. Nlrp3-/- (cryopyrin) mice are useful for studying role of the inflammasome in immune responses. New floxed strains include Cxcl12, Csf1r and a floxed-stop ubiquitous Myc-driven human CD2 KI. Cxcl12 functions in lymphoid progenitor and hematopoietic SC maintenance. The cytokine, Csf1r, is associated with macrophage function. Other additions include: a tamoxifen-inducible KI of EGFP/cre/ERT into the Foxp3 locus, a transcription factor required for development and function of Treg cells; a Notch reporter with GFP expression directed to the Notch pathway; an RORgamma-driven cre transgene that directs expression to αβ T cells, immature thymocytes and lymphoid tissue inducer cells. To have your strain considered for inclusion in the Repository please visit www.jax.org/donate-a-mouse.
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