Abstract
Abstract The Jackson Laboratory Repository serves as a centralized facility for the development, distribution and cryopreservation of mouse models of human biology and disease. Hundreds of new strains are added annually to one of the largest collections of characterized mouse strains available. This poster presents our newest knockout (KO) strains involving genes associated with cell-mediated and humoral immunity. Lag3 (lymphocyte activation 3) KO mice allow further characterization of Treg suppressive function. Pvr (CD155)-null mice carry a lacZ reporter and exhibit inefficient IgA/IgE responses in response to challenge. The loxP-flanked Bcl6 mice carry a conditional allele involved in the differentiation of CD4 T cells into follicular Th cells. Two strains provide reporter/KO mutants of genes involved in the complement pathway, C1qa and Cfb. In addition, the hematopoietic cytokine, Il3, joins our extensive collection of interleukin mutants. New research tools include the following: a strain with EGFP and cre expression from the Zbtb16 (PLZF) promoter, in which expression is directed to the NKT cell lineage; a cre knockin (KI) into the Cx3cr1 promoter region for fate-mapping studies of the monocyte/macrophage compartment; and a ROSA26 KI that features a two-color fluorescent Cre reporter (widespread red fluorescence prior to cre exposure and localized green fluorescence following cre exposure). Researchers are encouraged to deposit mice to the Repository: www.jax.org/donate-a-mouse.
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