Abstract
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism genetic and genome resource for the laboratory mouse. MGD is the authoritative source for biological reference data sets related to mouse genes, gene functions, phenotypes, and mouse models of human disease. MGD is the primary outlet for official gene, allele and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. In this report we describe significant enhancements to MGD, including two new graphical user interfaces: (i) the Multi Genome Viewer for exploring the genomes of multiple mouse strains and (ii) the Phenotype-Gene Expression matrix which was developed in collaboration with the Gene Expression Database (GXD) and allows researchers to compare gene expression and phenotype annotations for mouse genes. Other recent improvements include enhanced efficiency of our literature curation processes and the incorporation of Transcriptional Start Site (TSS) annotations from RIKEN’s FANTOM 5 initiative.
Highlights
The Mouse Genome Database (MGD) is the community model organism knowledgebase for the laboratory mouse
The rigorous application of nomenclature and annotation standards in MGD ensures that the information in the resource is curated consistently to support robust and comprehensive data retrieval for sets of genes that share biological properties and data mining for knowledge discovery
In this report we describe significant enhancements to MGD, including two new graphical user interfaces: (i) the Multiple Genome Viewer for exploring the genomes of multiple mouse strains and (ii) the Phenotype/Gene Expression matrix which allows users to compare gene expression and phenotype annotations for mouse genes
Summary
The Mouse Genome Database (MGD) is the community model organism knowledgebase for the laboratory mouse. MGD is a core resource within the Mouse Genome Informatics (MGI) consortium (http://www.informatics.jax.org). Gene model structure details and sequences for all 19 annotated mouse genomes are accessible from MGI’s MouseMine (http://www.mousemine.org) through its user interface and web services (MouseMine web services back the Multiple Genome Viewer).
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