Abstract
The induction of micronuclei in mouse bone marrow was studied after whole-body exposure to low doses of gamma radiation, ranging from 5 to 75 cGy. Micronuclei were scored at 10 and 30 h after irradiation. A linear dose response was obtained at both postirradiation times. However, the number of micronuclei per 100 nuclei was lower at 30 h than at 10 h, and the dose-response curve for the former had a shallower slope. When fitted to the alpha D + beta D2 model, a negative beta value was obtained. This could be due to division delay, combined with elimination of damaged cells by death at higher doses.
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