Abstract
The genetic control of alpha‐fetoprotein (AFP) synthesis in the mouse is studied. Structural variants of mouse AFP have not yet been found, although 22 inbred strains have been tested for the presence of such variants. In constrast, a mouse strain has been found, in which the regulation of AFP synthesis is altered. In this mouse strain the rate at which AFP synthesis is turned off after birth is decreased, as compared to other inbred mouse strains. This property is controlled by a single recessive Mendelian gene, which has been called Raf (for regulation of alpha‐fetoprotein synthesis). The conclusion that Raf is a single recessive Mendelian gene is supported both by genetic data published previously and by new genetic data presented in this paper. The Raf gene not only controls the rate at which AFP synthesis is turned off after birth, but also controls the amount of AFP produced under conditions of liver regeneration. Thus, characterization of the Raf gene can shed light both on the mechanism that turns off AFP synthesis after birth and on the mechanisms that control regeneration of the liver.
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