Abstract
Motor Unit Number Estimation (MUNE) Free of Electrical Stimulation or M Wave Recording: Feasibility and Challenges.
Highlights
The motor unit is the basic organizational and functional element for neuromuscular control
By making rational use of such information, we argue that it is feasible to perform motor unit number estimation (MUNE) without any electrical stimulation
By proposing a novel strategy to perform MUNE without recording the compound muscle action potential (CMAP), we argue that stimulation-free MUNE is feasible
Summary
The motor unit is the basic organizational and functional element for neuromuscular control. Motor unit loss can be partially compensated by axonal branching and muscle fiber reinnervation, such compensation becomes insufficient with disease progression. Patients suffer from progressive muscle weakness and loss of function. The number of motor units provides an important biomarker for diagnosing neuromuscular disease, tracking disease progression, and evaluating the effect of treatments and therapies (Olney and Lomen-Hoerth, 2000; Cudkowicz et al, 2006; Neuwirth et al, 2015). This has led to significant efforts in the past 50 years toward motor unit number estimation (MUNE)
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