Motor Learning In Duchenne Muscular Dystrophy - A Literature Review

Silvia Regina Pinheiro Malheiros,Camila Miliani Capelini,Luiz Carlos De Abreu,Carlos Bandeira De Mello Monteiro,Thais Massetti,Talita Dias Da Silva,Denise Cardoso Ribeiro,Bruna Leal De Freitas,Mayra Priscila Bolcolo Alvarez,Rubens Wajnsztejn

doi:10.3823/1816

Abstract

OBJECTIVE: To present and discuss the outcomes in the literature regarding the process of motor learning and/or motor ability in people with Duchenne muscular dystrophy (DMD). METHOD: A timeless search was performed in the electronic databases PubMed and BVS (Virtual Health Library), with the keywords “Duchenne muscular dystrophy” (Duchenne Muscular Dystrophy), “motor learning” (learning engine), “motor skills” (ability motor). We used the Boolean AND / OR, and / or to give more specific research and sensitivity to the survey, and papers were only accepted in Portuguese and English. The studies were reviewed independently by two researchers, and after reading the titles and abstracts, they identified the works that were included for analysis and scoring. RESULTS: The search yielded 18 articles and four studies met all inclusion criteria. The results show that DMD maintains motor learning patterns, even with the progressive dysfunction. They also focus on lower performance compared to individuals with normal development. However, there are differences in the impact and magnitude of the influence of factors such as cognitive ability, deterioration of the perceptual motor process and kinetic impairment in the motor learning of people with DMD. CONCLUSION: The process of motor learning in people with DMD remains, even with the progressive nature of the disease, and it is essential to further clarify how this process takes place, as well as the variables behave.

Highlights

The results show that Duchenne muscular dystrophy (DMD) maintains motor learning patterns, even with the progressive dysfunction
Duchenne muscular dystrophy (DMD) is an inherited recessive genetic disease characterized by the absence of dystrophin protein in muscle fiber membrane resulting from mutation of the gene Xp21 [1, 2]
The results showed that people with DMD presented a perceptual motor learning curve similar to individuals with typical development but with lower performance

Summary

Introduction

Duchenne muscular dystrophy (DMD) is an inherited recessive genetic disease characterized by the absence of dystrophin protein in muscle fiber membrane resulting from mutation of the gene Xp21 [1, 2]. Its incidence is approximately 1 in 3,500 live birth boys [1]. In this condition, the musculoskeletal system gradually degenerates and weakens with age [3]. The progressive and irreversible weakening of the skeletal, respiratory and cardiac muscles leads to a severe physical disability and shorter life expectancy [4]. Due to the progressive nature of the disease, the person is confined to a wheelchair from about 10 to 13 years old [5, 6]. To enable a person with DMD to achieve greater functionality in everyday tasks, the existence of studies investigating therapeutic interventions and their effectiveness in terms of rehabilitation, taking into account the needs and specificities of the disease’s progression, is critical

Methods

Results

Discussion

Conclusion