Abstract
The maximal electroshock on mice and rats is a recognized method for screening new compounds for their activity against “grand mal” epilepsy. Frequently, however, compounds which cannot be classed as anti-epileptic agents also exhibit a protective effect. The attempt was made to differentiate between the true anti-epileptic drugs and other “anti-extensors” by recording the electrocorticogram in the rat simultaneously with the transcorneal electroshock. The results showed that the clinically proved anti-epileptic drugs (phenobarbital, phenytoin, phensuximide, primidone, phenacemide, sulthiame, carbamazepen and trimethadione) had no influence on the electrographic convulsive activity in the cortex, even in doses up to 8-fold the ED 50. The role of the mesencephalon in the development of motoric convulsions following electroshock is briefly discussed.
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