Abstract
The effects of intraventricular injections of various doses (20.00, 5.00, 1.25, 0.30 and 0.07 μg) of synthetic Substance P on motor activity in rats were investigated. Activity scores as determined by photocell counts recorded for a 15 min test period were significantly increased in animals injected with 0.30 and 1.25 μg/rat Substance P. The other doses examined did not affect activity. Doses in the range of 40–80 μg produced immobility, rigidity and barrel rotations. Hypersalivation as indicated by a wet fur following an episode of grooming was observed in several animals. Administration of Substance P, in a dose of 0.60 μg, in combination with or 30 min after injections of 2 mg/kg d-amphetamine and 1 mg/kg apomorphine did not potentiate or reduce the increased activity and stereotypy induced by these two drugs.
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