Motivational state-dependent renewal and reinstatement of operant responding under food and water deprivation states

Abstract

Most studies of operant relapse phenomena have studied the role of exteroceptive discriminative features of context in the recovery of behavior after extinction. Interoceptive stimuli (i.e., stimuli arising from the bodies of organisms) may also serve as a part of learning contexts and contribute to relapse. Recent studies have demonstrated that events that function as motivating operations (MOs) may contribute to relapse both by a) eliciting interoceptive conditions that serve as a discriminative context for relapse (i.e., discriminative function) and b) altering the amount of operant responding in the presence of discriminative stimuli associated with reinforcers (i.e., motivational function). The current study examined interactions between these functions of food and water deprivation MOs in the relapse of operant behavior. During acquisition of an operant response, one group of mice was food-deprived and another was water-deprived. The groups then received extinction sessions under the opposite condition. Renewal and reinstatement tests were conducted under both conditions, and more renewal and reinstatement were observed in the motivational states in which acquisition occurred for each. These results are discussed in the context of state-dependent learning.