Motion corrected silent ZTE neuroimaging.

Abstract

PurposeTo develop self‐navigated motion correction for 3D silent zero echo time (ZTE) based neuroimaging and characterize its performance for different types of head motion.MethodsThe proposed method termed MERLIN (Motion Estimation & Retrospective correction Leveraging Interleaved Navigators) achieves self‐navigation by using interleaved 3D phyllotaxis k‐space sampling. Low resolution navigator images are reconstructed continuously throughout the ZTE acquisition using a sliding window and co‐registered in image space relative to a fixed reference position. Rigid body motion corrections are then applied retrospectively to the k‐space trajectory and raw data and reconstructed into a final, high‐resolution ZTE image.ResultsMERLIN demonstrated successful and consistent motion correction for magnetization prepared ZTE images for a range of different instructed motion paradigms. The acoustic noise response of the self‐navigated phyllotaxis trajectory was found to be only slightly above ambient noise levels (<4 dBA).ConclusionSilent ZTE imaging combined with MERLIN addresses two major challenges intrinsic to MRI (i.e., subject motion and acoustic noise) in a synergistic and integrated manner without increase in scan time and thereby forms a versatile and powerful framework for clinical and research MR neuroimaging applications.