Motility changes associated with canine intestinal allografting

Abstract

Intraluminal pressures in segments of normal resting jejunum were measured by small balloon-tipped catheters. In most animals, ischemia produced a hyperperistaltic response which subsided during perfusion with cold Ringer's solution. Within 5 min after revascularization, intraluminal pressures increased threefold, with wide fluctuations, reflecting vigorous peristalsis. Intramural electrical activity was monitored using Teflon coated stainless steel wire electrodes. Complete severance of extrinsic innervation resulted in definite increase in action potentials and in some cases slow waves became irregular and decreased slightly in amplitude. Initially, ischemia produced vigorous spiking which disappeared during a 60-min perfusion period. Revascularization resulted in reappearance of electrical activity and vigorous peristalsis. Action potentials were prominent, while slow waves were irregular, of diminished amplitude and reduced in frequency. Necrosis of the segment secondary to rejection was associated with loss of electrical activity; based on gross appearance smooth muscle appeared more resistant to rejection than mucosa. Alterations of motility did not appear to be useful in early prediction of rejection.