Abstract
BackgroundGestational diabetes mellitus (GDM) is defined as glucose intolerance with its onset or first recognition during pregnancy. Post-GDM women have a life-time risk exceeding 70% of developing type 2 diabetes mellitus (T2DM). Lifestyle modifications reduce the incidence of T2DM by up to 58% for high-risk individuals.Methods/DesignThe Mothers After Gestational Diabetes in Australia Diabetes Prevention Program (MAGDA-DPP) is a randomized controlled trial aiming to assess the effectiveness of a structured diabetes prevention intervention for post-GDM women. This trial has an intervention group participating in a diabetes prevention program (DPP), and a control group receiving usual care from their general practitioners during the same time period. The 12-month intervention comprises an individual session followed by five group sessions at two-week intervals, and two follow-up telephone calls. A total of 574 women will be recruited, with 287 in each arm. The women will undergo blood tests, anthropometric measurements, and self-reported health status, diet, physical activity, quality of life, depression, risk perception and healthcare service usage, at baseline and 12 months. At completion, primary outcome (changes in diabetes risk) and secondary outcome (changes in psychosocial and quality of life measurements and in cardiovascular disease risk factors) will be assessed in both groups.DiscussionThis study aims to show whether MAGDA-DPP leads to a reduction in diabetes risk for post-GDM women. The characteristics that predict intervention completion and improvement in clinical and behavioral measures will be useful for further development of DPPs for this population.Trial registrationAustralian New Zealand Clinical Trials Registry ANZCTRN 12610000338066
Highlights
Introduction to diabetes prevention program (DPP)Assessment of personal risk of developing type 2 diabetes mellitus (T2DM)Highlight the five program goals: Reduce weight by 5% Reduce total fat intake to < 30% daily energy intake Reduce saturated fat intake to < 10% daily energy intake Increase fiber intake to > 15 g per 1000 kcal Increase physical activity to at least 30 minutes moderate intensity physical activity on at least 5 days per weekBuild commitment to attend the program by discussed perceived benefits and importance of attendingEstablish personal weight goal for the after 3 monthsSet physical activity goalGroup session 1
This study aims to show whether Mothers After Gestational Diabetes in Australia (MAGDA)-DPP leads to a reduction in diabetes risk for post-Gestational diabetes mellitus (GDM) women
The characteristics that predict intervention completion and improvement in clinical and behavioral measures will be useful for further development of DPPs for this population
Summary
Build commitment to attend the program by discussed perceived benefits and importance of attendingEstablish personal weight goal (current weight minus 5%) for the after 3 monthsSet physical activity goalGroup session 1 (held in community venue within 1 month of individual session). Gestational diabetes mellitus (GDM) is defined as glucose intolerance with its onset or first recognition during pregnancy. Post-GDM women have a life-time risk exceeding 70% of developing type 2 diabetes mellitus (T2DM). Depending on the population studied, 1 to 14% of all pregnancies are complicated by GDM [1] This estimate may double if the International Diabetes Association of Diabetes and Pregnancy Study Groups (IDAPSG) recommended criteria are implemented [2]. Gestational diabetes mellitus is defined as glucose intolerance of variable severity with onset or first recognition during pregnancy [3]. Post-GDM women have a life-time risk of developing T2DM exceeding 70% [4].
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