Abstract
Objective. To analyze the age structure of the mothers of children with birth defects and to assess the age-related risks of chromosomal and non-chromosomal congenital anomalies.Material and methods. The authors analyzed the data from 23 regional registers of birth defects from 2011 to 2018. There were total 5 047 468 births during this period. The authors calculated the incidence and relative risks of chromosomal and non-chromosomal birth defects in different age groups of mothers: under 20, from 20 to 34, from 35 to 39, 40–44, and above 45 years old.Results. The incidence of chromosomal abnormalities significantly increases with the mother’s age. The relative risk (RR) of chromosomal abnormalities in different age groups: 4,67 (95% CI 4,44–4,92) in Group 35-39, 15,00 (95% CI 14,10–15,96) in Group 40–44, and 26,49 (95% CI 21,89–32,07) in Group ≥45 as compared with the main age group of 20–34 years old. The authors also revealed the dependence of the non-chromosomal birth defects on the age of the mother: RR 1,15 (95% CI 1,08–1,23) in Group <20 years, RR 1,18 (95% CI 1,13–1,23) in Group 35–39, RR 1,35 (95% CI 1,24–1,47) in Group 40–44, and RR 2,03 (95% CI 1,47–2,79) in Group ≥ 45 years old.Conclusion. The study demonstrates the dependence of chromosomal and non-chromosomal birth defects on the mother’s age.
Highlights
The relative risk (RR) of chromosomal abnormalities in different age groups: 4,67 (95% CI 4,44–4,92) in Group 35-39, 15,00 (95% CI 14,10–15,96) in Group [40–44], and [26,49] (95% CI 21,89–32,07) in Group ≥45 as compared with the main age group of [20–34] years old
The relative risk (RR) of chromosomal abnormalities in different age groups: 4,67 in Group 35-39, 15,00 in Group [40–44], and [26,49] in Group ≥45 as compared with the main age group of [20–34] years old
The authors also revealed the dependence of the non-chromosomal birth defects on the age of the mother: RR 1,15 (95% CI 1,08–1,23) in Group
Summary
Анализ возрастной структуры матерей детей с врожденными пороками развития для оценки возрастных рисков врожденных аномалий хромосомной и нехромосомной природы по данным мониторинга. Частоты и относительные риски пороков развития хромосомной и нехромосомной природы рассчитывались в различных возрастных группах матерей: моложе 20 лет, от 20 до 34 лет, 35–39 лет, 40–44 года и старше 45 лет. Зависимость от возраста матери выявлена и для врожденных пороков развития нехромосомной этиологии: у матерей моложе 20 лет ОР составил [1,15] (95% ДИ 1,08–1,23), в группе [35–39] лет [1,18] (95% ДИ 1,13–1,23), в группе [40–44] года [1,35] (95% ДИ 1,24–1,47), у матерей старше 45 лет 2,03 (95% ДИ 1,47–2,79). Анализ данных мониторинга выявил зависимость частоты врожденных пороков развития хромосомной и нехромосомной этиологии от возраста матери.
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