Abstract

BackgroundThe most common problem about conventional dosage form is dysphagia (difficulty in swallowing). So, we design a new approach in a conventional dosage form which is oral dispersible tablet. Oral dispersible tablet is also called as mouth dissolving tablet, fast dissolving tablet, or oral disintegrating tablet. Oral dispersible tablet has advantage as it quickly disintegrates into saliva when it is put on the tongue. The faster the drug disintegrates or is dissolved, the faster the absorption and the quicker the therapeutic effect of drug will be attained.Main textThis review article focuses on the progress in methods of manufacturing and various latest technologies involved in the development of oral disintegrating tablet. The solid dispersion technique is one of the novel techniques to manufacturing the oral dispersible tablet. Solid dispersion is basically a drug polymer two component system.ConclusionThis review article focuses on advantages, disadvantages, materials used as carrier for solid dispersions, methods of preparation of solid dispersion, classification of solid dispersion, promising drugs that can be incorporated into oral disintegrating tablet by solid dispersion techniques, and recent research in solid dispersion technique using polymers as carriers.

Highlights

  • This review article focuses on the progress in methods of manufacturing and various latest technologies involved in the development of oral disintegrating tablet

  • This review article focuses on advantages, disadvantages, materials used as carrier for solid dispersions, methods of preparation of solid dispersion, classification of solid dispersion, promising drugs that can be incorporated into oral disintegrating tablet by solid dispersion techniques, and recent research in solid dispersion technique using polymers as carriers

  • 2.1 Solid dispersion Chiou and Reigelman first defined solid dispersion as “dispersion of one or more active ingredients in an inert carrier or matrix at solid state prepared by fusion, solvent or melting solvent method” [4,5,6], or solid dispersion defined as “a dispersion that include the formation of eutectic mixtures of drug with carriers that soluble in water by melting of their physical mixtures” [7, 8]

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Summary

Main text

2.1 Solid dispersion Chiou and Reigelman first defined solid dispersion as “dispersion of one or more active ingredients in an inert carrier or matrix (hydrophilic) at solid state prepared by fusion, solvent or melting solvent method” [4,5,6], or solid dispersion defined as “a dispersion that include the formation of eutectic mixtures of drug with carriers that soluble in water by melting of their physical mixtures” [7, 8]. Nikam et al Beni-Suef University Journal of Basic and Applied Sciences (2020) 9:62. PVP, PEG, HPMC, hydroxy ethyl cellulose, cyclodextrins, pectin, galactomanan, etc. HPMC pthalate, Eudragit L100, Eudragit E100, Eudragit RL, Eudragit RS, etc. Pentaerythritol, pentaerythritol tetraacetate, urea, urethane, hydroxy alkyl xanthins, etc

Conclusion
Background
Demerits of solid dispersion
31 Piroxicam 32 Atrovastatin
56 Nevirapine
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