Mossy cells of the hippocampal dentate gyrus are not selectively vulnerable in human mesial temporal lobe epilepsy

Abstract

Event Abstract Back to Event Mossy cells of the hippocampal dentate gyrus are not selectively vulnerable in human mesial temporal lobe epilepsy Hajnalka Ábrahám1*, Laszlo Seress1, Zsolt Horvath1, Tamas Doczi1, Jozsef Janszky2, Joyce Klemm3, Richard Byrne3 and Roy A. Bakay3 1 Department of Neurosurgery, University of Pécs, Hungary 2 Department of Neurology , University of Pécs, Hungary 3 Deparment of Neurosurgery, Rush Presbyterian-St. Luke’s Medical Center, United States Hippocampal sclerosis is a common pathology in temporal lobe epilepsy. It is generally believed that there are epilepsy-prone and epilepsy-resistant neurons in the hippocampal formation. Mossy cells of the hippocampal dentate gyrus are considered to be one of the most vulnerable neurons. Since selective histological marker for mossy cells was not available, it was previously difficult to assess whether mossy cells are among the remaining hilar neurons in the epileptic hippocampus. It has recently been described that the cocaine- and amphetamine-regulated transcript peptide (CART) is a reliable marker for human mossy cells. Therefore, we performed histological evaluation of resected epileptic hippocampi using CART immunocytochemistry to identify mossy cells. Cytoarchitecture and neuronal loss was determined with NeuN immunohistochemistry and Nissl staining. In most cases, the number of mossy cells was reduced and the thorny excrescences were smaller in epileptic hippocampi than in controls. Significant loss of pyramidal cells and partial loss of granule cells were accompanied by mossy cell loss. However, in many cases large numbers of mossy cells were still present in the dentate gyrus when most pyramidal neurons of Ammon’s horn were lost suggesting that mossy cells may not be more sensitive for epileptic seizures than the hippocampal pyramidal neurons. Thus, mossy cells are vulnerable to seizures, but a group of them appears to survive even decades of epilepsy. Supported by ETT grant 219/2006 (J. Janszky.) and OTKA grants F 68720 (J. Janszky), PD 73384 (H. Ábrahám) and by Bolyai Scholarship (H. Ábrahám). Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Pathophysiology and neurology - degenerative disorders Citation: Ábrahám H, Seress L, Horvath Z, Doczi T, Janszky J, Klemm J, Byrne R and Bakay RA (2009). Mossy cells of the hippocampal dentate gyrus are not selectively vulnerable in human mesial temporal lobe epilepsy. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.135 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Mar 2009; Published Online: 04 Mar 2009. * Correspondence: Hajnalka Ábrahám, Department of Neurosurgery, University of Pécs, Pecs, Hungary, hajnalka.abraham@aok.pte.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hajnalka Ábrahám Laszlo Seress Zsolt Horvath Tamas Doczi Jozsef Janszky Joyce Klemm Richard Byrne Roy A Bakay Google Hajnalka Ábrahám Laszlo Seress Zsolt Horvath Tamas Doczi Jozsef Janszky Joyce Klemm Richard Byrne Roy A Bakay Google Scholar Hajnalka Ábrahám Laszlo Seress Zsolt Horvath Tamas Doczi Jozsef Janszky Joyce Klemm Richard Byrne Roy A Bakay PubMed Hajnalka Ábrahám Laszlo Seress Zsolt Horvath Tamas Doczi Jozsef Janszky Joyce Klemm Richard Byrne Roy A Bakay Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.