Mosquito proboscis-inspired needle insertion to reduce tissue deformation and organ displacement

Annie D R Li,Lei Chen,Albert Shih,Jeffrey S Montgomery,Ketut B Putra

doi:10.1038/s41598-020-68596-w

Annie D R Li, Lei Chen + Show 3 more

Open Access

https://doi.org/10.1038/s41598-020-68596-w

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Journal: Scientific Reports	Publication Date: Jul 22, 2020
Citations: 21	License type: open-access

Affiliation: University of Michigan–Ann Arbor

Abstract

This study investigates mosquito proboscis-inspired (MPI) insertion applied to the clinically used biopsy needle to reduce tissue deformation and organ displacement. Advanced medical imagining has enabled early-stage identification of cancerous lesions that require needle biopsy for minimally invasive tissue sampling and pathological analysis. Accurate cancer diagnosis depends on the accuracy of needle deployment to the targeted cancerous lesion site. However, currently available needle delivery systems deform and move soft tissue and organs, leading to a non-diagnostic biopsy or undersampling of the target. Two features inspired by the mosquito proboscis were adopted for MPI insertion in prostate biopsy: (1) the harpoon-shape notches at the needle tip and (2) reciprocating needle-cannula motions for incremental insertion. The local tissue deformation and global prostate displacement during the MPI vs. traditional direct insertions were quantified by optically tracking the displacement of particle-embedded tissue-mimicking phantoms. Results show that the MPI needle insertion reduced both local tissue deformation and global prostate displacement because of the opposite needle-cannula motions and notches which stabilized and reduced the tissue deformation during insertion. Findings provide proof of concept for MPI insertion in the clinical biopsy procedures as well as insights of needle–tissue interaction for future biopsy technology development.

Highlights

This study investigates mosquito proboscis-inspired (MPI) insertion applied to the clinically used biopsy needle to reduce tissue deformation and organ displacement
Transrectal ultrasound (TRUS) images fused with a targeted lesion identified by magnetic resonance imagining (MRI) from a clinical MRI-ultrasound fusion targeted biopsy (MRF-TB) procedure for prostate needle biopsy are shown in Fig. 1c–e for three needle positions during insertion
The local deformation of local tissue deformation (LTD) phantom during the needle insertion was quantified as the tissue strain and displacement in digital image correlation (DIC)

Summary

Introduction

This study investigates mosquito proboscis-inspired (MPI) insertion applied to the clinically used biopsy needle to reduce tissue deformation and organ displacement. Two features inspired by the mosquito proboscis were adopted for MPI insertion in prostate biopsy: (1) the harpoon-shape notches at the needle tip and (2) reciprocating needle-cannula motions for incremental insertion. Mosquito proboscis is an ideal needle device which minimizes the deformation and displacement of surrounding tissue during insertion for accurate guidance to targeted vessels. The proboscis advances incrementally with vibratory relative displacements of the labrum and maxillae for reciprocating tissue penetration[2,3]. Transrectal ultrasound (TRUS) images fused with a targeted lesion identified by MRI from a clinical MRF-TB procedure for prostate needle biopsy are shown in Fig. 1c–e for three needle positions during insertion.

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