Mosquito microbiome and its application in mosquito-bornediseases control

Abstract

<p indent="0mm">Mosquitoes are physically colonized by a complex population of microbes, which constitute a diverse and dynamic microbiome. Mosquito microbiome plays an important role in mosquito physiological functions including nutrition, metabolism, and immunity, and is indispensable for mosquito development and propagation. Meanwhile, the mosquito microbiome significantly affects the infection and transmission of mosquito-borne pathogens, thus has important application potential in the prevention and control of mosquito-borne diseases. Therefore, a comprehensive understanding of mosquito physiology and mosquito-borne diseases transmission cannot ignore the critical role of the microbiome. This review summarizes the advances of mosquito microbiome and its influencing factors, the influence of gut microbiome on host physiology and mechanisms underlying gut microbiota-host-pathogen interactions in mosquitoes. We also provide an overview on the use of microbiome in the prevention and control of mosquito-borne diseases. Finally, directions for future work are discussed.