Abstract
Surface Plasmon resonance (SPR) provides an efficacious and label-free detection method for optical fiber bio-sensing. MoSe 2 is one of the transition metal dichalcogenides (TMDCs) which has broad applications in detecting specific reactions. Cysteamine hydrochloride with enriched groups can generate self-assemble films for tight attachment. In this study we aimed to combine the rapid response of optical fiber SPR sensors with the enhanced sensitivity of MoSe 2 nano-films. An optical fiber SPR biosensor with MoSe 2 -Au nanostructure was proposed and implemented, and a sensitivity of 2821.81 nm/RIU was achieved, which was approximately 98.7% higher than that of conventional SPR sensor without using MoSe 2 nanostructure. Furthermore, Bovine Serum Albumin (BSA) was utilized as the target molecule to test the bioaffinity of the biosensor with MoSe 2 deposition cycles from 0 to 8. Weighing the sensitivity and the figure of merit (FOM), the best deposition cycle of MoSe 2 was 4 with the sensitivity of 2793.36 nm/RIU and FOM of 37.24 RIU -1 . At last, immunization experiments were carried out using Goat-anti-Rabbit IgG and a detection limit of 0.33 μg/mL was achieved. The rapid response and the high bioaffinity showed a strong applicability of the proposed MoSe 2 -Au SPR immune-sensor in specific interactions and immunization therapy.
Highlights
Surface Plasmon resonance (SPR) sensors have attracted much attention due to their real-time and rapid response for the detection of specific molecular interactions and the clinical diagnosis of disease [1]–[3]
Effective methods for enhancing the sensitivity can be divided into two categories [8], [9]: one is to optimize the internal structure of optical fiber, the other is to involve various sensitivity-improved materials
The results demonstrated a bright prospect of our developed optical fiber SPR biosensor for the protein detection and clinical diagnosis
Summary
Surface Plasmon resonance (SPR) sensors have attracted much attention due to their real-time and rapid response for the detection of specific molecular interactions and the clinical diagnosis of disease [1]–[3]. In contrast to the traditional prism structures with large size and complex operation, optical fibers exhibit superiorities in the miniaturization, the cost efficiency and the immunity to electromagnetic interferences. The existing optical fiber SPR sensors face a big challenge in sensitivity. Effective methods for enhancing the sensitivity can be divided into two categories [8], [9]: one is to optimize the internal structure of optical fiber, the other is to involve various sensitivity-improved materials
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