Abstract
A 25-year-old pregnant woman with a history of five previous miscarriages was admitted to our clinic. She had undergone abortion in her first pregnancy at 14 weeks gestation due to anhydramnios. Her second pregnancy had ended in a miscarriage at 19 weeks gestation due to premature rupture of membranes. Both of her first two pregnancies showed normal karyotypes. Her third pregnancy was noted to be an ectopic pregnancy leading to abortion at 5 weeks gestation. Afterwards, she experienced two more miscarriages at 7 weeks of gestation due to the lack of fetal cardiac activity which could not been investigated for chromosomal abnormalities.
 Her current pregnancy was also terminated at 9 weeks of gestation due to the lack of fetal cardiac activity. Cytogenetic analysis of abortion material using GTG banding technique revealed 48,XY,+12,+15[5]/46,XY[25] karyotype (7). Both parents were found to have normal karyotypes and physical examinations showed no obvious abnormalities. Thrombophilia evaluation revealed that she had heterozygous MTHFR C677T polymorphism.
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