MoS2-Catalyzed transamidation reaction

Feng Zhang,Juan Ma,Lesong Li,Hang Gong

doi:10.1038/s41598-019-39210-5

Feng Zhang, Juan Ma + Show 2 more

Open Access

https://doi.org/10.1038/s41598-019-39210-5

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Abstract

The MoS2-catalyzed transamidation reaction with high yields using N,N-dimethylformamide and other amides as carbonyl sources is developed here. The protocol is simple, does not require any additive such as acid, base, ligand, etc., and encompasses a broad substrate scope for primary, secondary and heterocyclic amines. Moreover, the acetylation and propanylation of amines also can be achieved with good to excellent yield by this strategy.

Highlights

The MoS2-catalyzed transamidation reaction with high yields using N,N-dimethylformamide and other amides as carbonyl sources is developed here
A highly efficient MoS2-catalyzed transamidation reaction using DMF and other amides as carbonyl sources has been developed (Fig. 2). This method has advantages such as using inexpensive catalyst and reagents, no need for any other additives. This strategy has a broad substrate scope that both primary and secondary amines with different groups are suitable for this reaction and good to excellent yields can be achieved
The results indicated that tetrahydroisoquinoline or its analogs could be converted to desired product with good to excellent yields (2a–f)

Summary

Introduction

The MoS2-catalyzed transamidation reaction with high yields using N,N-dimethylformamide and other amides as carbonyl sources is developed here. The catalyzed transamidation reactions using DMF as carbonyl source have been reported. A highly efficient MoS2-catalyzed transamidation reaction using DMF and other amides as carbonyl sources has been developed (Fig. 2). This strategy has a broad substrate scope that both primary and secondary amines with different groups are suitable for this reaction and good to excellent yields can be achieved.

Results

Conclusion