Abstract
Morusin, a preylated flavonoid, is extracted from Cortex Mori, which is used in traditional Chinese medicine. In addition, morusin has been demonstrated to induce apoptotic effect in some cancers such as liver cancer, but other anticancer action is not well understood. In our preliminary study, we found Cortex Mori ethanolic extract and morusin exhibited cytotoxicity and antimigration effects in SK-Hep1 cells. Moreover, 5, 10, and 15 μM of morusin reduced cell mobility, migration and invasion by analysis wound healing assay and boyden chamber assay in SK-Hep1 cells. Accordingly, cell migration, and adhesion as well as angiogenesis require the formation of a leading pseudopodium, angiogenesis growth factor. Our results showed morusin significantly inhibited lamellipodia and filopodia formation, cell-matrix adhesion and angiogenesis. Furthermore, morusin can also inhibit growth factors and focal adhesion kinase (FAK) phosphorylation, and integrins and VEGF expression. By zymography assay and western blot assay, morusin inhibited MMP2 and MMP9 activation expression. Finally, we also found morusin inhibited c-Met and EGFR activation, and down stream activation decreased ERK, Akt, NF-κB, FAK, and Stat3. In conclusion, our data demonstrated morusin can reduce invasive growth of malignant liver through signaling inhibition.
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