Mortality risk factors for tuberculosis patients under treatment in the Kenya health zone, Lubumbashi, DRC

Abstract

Context and objective of the study: Tuberculosis remains a major public health problem in the world and in the DRC in particular. Tuberculosis lethality is an important indicator of its control. The objectives of this study were to determine the lethality rate of tuberculosis and to identify the risk factors for death in tuberculosis patients. under treatment in Kenya Health Zone. Methods: This is a case-control study from January 1, 2014 to December 31, 2016. The characteristics of patients aged at least 15 years and who died of tuberculosis during treatment were compared to those who had progressed well. We have exhaustively collected 59 deceased (Cases). The 177 controls were selected according to certain criteria of similarity among tuberculosis patients over 14 years of age who had progressed well. Chi-square tests, Fisher Exact, Wilcoxon, OR and its 95% CI as well as logistic regression were used to analyze our results. For all statistical tests, the significance level was set at 5%. Results: From 2014 to 2016, the rate of overall lethality was3.34% with a decreasing trend. Ihe socio-demographic and anthropometric characteristics: Follow-up care at CST Kalebuka [ORa1.33 (<0.001 - >1000.00), p=0.99],weight loss between the 1st and 2nd phase of treatment [ORa0.94, CI (0.018 - 48.48), p=0.97];clinical and therapeutic characteristics: The concept of counting [ORa1.68, CI (<0.001 - >1000.00), p=0.98],the therapeutic diet2SRHZE/RHZE/5RHE » [ORa>1000.00, CI (<0.001 - >1000.00), p=0.59], irregular compliance with treatment [ORa6.54, CI (<0.001 - >1000.00), p=0.95] did not were not significantly associated with tuberculosis mortality after logistic regression, and therefore constituted confounding factors Conclusion: The decrease in lethality observed during the 3 years reflects a good evolution of the fight. Aprospective study investigating tuberculosis mortality taking into account all possible determinants and aspects will make it possible to identify the factors significantly linked to death and develop additional treatment and follow-up strategiesto further reduce lethality due to tuberculosis.