Abstract
Neuromuscular transmission, muscle electrical activity and muscle mechanical properties have been studied in mice after the intraperitoneal transference of sera from myasthenic patients. Measurements of mepp's amplitude appear to be a suitable method for myasthenia gravis diagnosis since a high percentage of the sera from these patients caused a decrease in mepp's amplitude. The increase of the premenstrum weakness in myasthenic patients did not appear to be associated with greater fall of mepp's amplitude, since serum obtained in the premenstruum and far from it produced similar results. Myasthenic serum did not modify the electrical properties of innervated muscle sarcolemma. The resting membrane potential and the action potential parameters remained unchanged. However, tetrodotoxin resistant-action potentials of denervated muscles was reduced by myasthenic serum, possibly in association with receptor endocytosis process induced by the immunoglobulin. Muscle mechanical properties did not show alterations, even in the presence of positive titer of anti-striated muscle antibody.
Highlights
Over the last 2 decades after regaining independence, Lithuania entered a new era with many opportunities for radical improvements; the population of the country has been exposed to the new and unfamiliar social environment, and experienced tremendous stress [1, 2]
Despite the considerable transformations of socioeconomic situation and economic crisis, it is likely that Lithuania is entering into the stage of positive health development
The following established cases of major causes of death were included in the analysis: cardiovascular diseases (CVD), cancer, and external causes of death
Summary
Over the last 2 decades after regaining independence, Lithuania entered a new era with many opportunities for radical improvements; the population of the country has been exposed to the new and unfamiliar social environment, and experienced tremendous stress [1, 2]. The first decade of independence was the period of major socioeconomic changes, and it was expected that society would gradually enter a more stable stage of development. Mortality is one of the major indicators reflecting the changes in health outcomes. Several studies carried out in Lithuania have analyzed trends in mortality from major causes [3,4,5,6,7].
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