Abstract
PurposeThe lifespan of people with severe mental illness (SMI) is shorter compared to the general population. There might be common familial pathway leading to a high co-occurrence of somatic disorders and SMI. To study this we explored the long-term mortality for natural causes in the offspring of people with SMI.MethodsParticipants were members of the Northern Finland Birth Cohort 1966 (NFBC1966; N = 11,325). The data on cause of deaths of the members were obtained from the Population Register Center until year 2015. The data on hospital-treated psychiatric disorders of parents were obtained from nationwide Care Register for Health Care. Cumulative incidences by age were calculated in the NFBC1966 members having a parent with SMI and those who did not have. We were able to take into account multiple confounders.ResultsOf the total sample of 11,325 offspring, 853 (7.4%) died during the follow-up period, 74 (8.7%) from the study cohort and 779 (91.3%) from the comparison group. These numbers included 160 stillborn children. There were 557 cases of deaths from diseases and medical conditions and 296 deaths from external causes. The adjusted risk ratio for offspring of mothers with SMI was 1.08 (0.72–1.64), and for offspring of fathers with SMI 0.58 (0.36–0.93).ConclusionsThis was the first long-term follow-up study (up to age 49) of all-cause mortality in offspring of parents with SMI. Our findings were contrary to expectations. Offspring of parents with SMI had no increased risk for dying. In fact, the risk for dying in the group of offspring of fathers with SMI was lower than in the comparison group. This study does not support the assumption of common familial pathway leading to a high co-occurrence of somatic disorders and SMI.
Highlights
The lifespan of people with severe mental illness (SMI; schizophrenia. bipolar disorder, major depressive disorder) is shorter compared to the general population, and this is mostly due to physical illness [1]
We examined if offspring of people with severe mental have excess risk for mortality compared to the reference group
Mothers of the offspring of parents with SMI were more likely to continue smoking during pregnancy and have lower education level
Summary
The lifespan of people with severe mental illness (SMI; schizophrenia. bipolar disorder, major depressive disorder) is shorter compared to the general population, and this is mostly due to physical illness [1]. Bipolar disorder, major depressive disorder) is shorter compared to the general population, and this is mostly due to physical illness [1]. The diseases, that are more prevalent among people with SMI compared to the general population, are nutritional and metabolic diseases, cardiovascular diseases. Patients with major mental illnesses have an increased prevalence of overweight and obesity, hyperglycemia, dyslipidemia, hypertension and smoking. People with SMI might face other than disease-related factors such as poverty and reduced access to medical care, as well as adverse metabolic side effects associated with psychotropic medications [3]. There is evidence that patients with physical illness are more likely to receive delayed diagnosis, and this is due to poorer access to and quality of received health care [4]
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