Abstract
BackgroundIn Reunion Island, a French overseas department, the burden of preterm birth and perinatal mortality exceed those observed in mainland France, despite similar access to standard perinatal care. The purpose of the study was to compare the outcome of two cohorts of NICU-admitted very preterm infants born between 24 and 31 weeks of gestation (WG): the registry-based OGP (Observatoire de la Grande Prématurité, Reunion Island, 2008–2013) cohort, and the nationwide EPIPAGE-2 (mainland France, 2011) observational cohort.MethodsThe primary outcome was adverse neonatal outcomes defined as a composite indicator of in-hospital mortality or any of three following severe morbidities: bronchopulmonary dysplasia (BPD), necrotising enterocolitis, or severe neurological injury (periventricular leukomalacia or grade III-IV intraventricular haemorrhages). Logistic regression modelling adjusting for confounders was performed.ResultsA total of 1272 very preterm infants from the Reunionese OGP cohort and 3669 peers from the mainland EPIPAGE-2 cohort were compared. Adverse neonatal outcomes were more likely observed in the OGP cohort (32.6% versus 26.6%, p < 0.001), as result of both increased in-hospital mortality across all gestational age strata and increased BPD among the survivors of the 29–31 WG stratum. After adjusting for gestational age, gender and multiple perinatal factors, the risk of adverse neonatal outcomes was higher in the OGP cohort than in the EPIPAGE-2 cohort across all gestational age strata.ConclusionsDespite similar guidelines for standard perinatal care, very preterm infants born in Reunion Island have a higher risk for death or severe morbidity compared with those born in mainland France.
Highlights
In Reunion Island, a French overseas department, the burden of preterm birth and perinatal mortality exceed those observed in mainland France, despite similar access to standard perinatal care
A total of 1272 very preterm (VPT) infants were enrolled in the Reunionese Observatoire de Grande Prématurité (OGP) cohort with a completeness > 95.0%, while in the mainland EPIPAGE-2 cohort, 3669 VPT infants were included and the participation was 96% [11]
OGP cohort First, we analysed the temporal trends of the primary composite outcome in relation to the obstetric and neonatal factors known to be associated with adverse neonatal outcome over three two-year time frames (2008–2009, 2010– 2011 and 2012–2013) in the Additional file 2: Table S2
Summary
In Reunion Island, a French overseas department, the burden of preterm birth and perinatal mortality exceed those observed in mainland France, despite similar access to standard perinatal care. The purpose of the study was to compare the outcome of two cohorts of NICU-admitted very preterm infants born between 24 and 31 weeks of gestation (WG): the registry-based OGP (Observatoire de la Grande Prématurité, Reunion Island, 2008–2013) cohort, and the nationwide EPIPAGE-2 (mainland France, 2011) observational cohort. Advances in the management of severe prematurity have substantially reduced mortality in very preterm (VPT) infants, while pushing the limit of viability to ever-lower gestational ages. Care practices and management of VPT infants differ between nations, regions within a same country, and hospital centres, explaining disparities in survival, especially at the extremes of viability [5]. Pregnancy-related conditions in the DOMs differ from those observed in mainland France, as mothers are younger, more often isolated, and have a lower level of education [7]
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