Abstract
Abstract In an historical cohort of 21,967 workers ever employed in 13 European factories manufacturing various types of man-made mineral fibres (MMMF), 2.719 deaths occurred (Standardised Mortality Ratio (SMR) = 111) of which 189 were from lung cancer (SMR = 125). No excess mortality from mesothelioma or non-malignant respiratory diseases was found. For the glasswool and rockwool/slagwool production subcohorts the lung cancer SMRs rose with time since first exposure, exceeding 170 for the period of 30 or more years. Adjustment for regional variations in mortality substantially reduced the excess in the glasswool group, but not in the rockwool/slagwool. In neither subgroup was there any relationship of lung cancer mortality with length of employment. The highest lung cancer SMRs were found for workers employed during the early years of rockwool/slagwool production when a batch process was in use involving high fibrous dust exposure and widespread use of slag as a raw material. This group accounted for most of the absolute excess of lung cancer for the rockwool plants.
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