Morphometric study on the postnatal growth of the cerebellum of Australian Aborigines and Caucasians

Abstract

In an autopsy study on 29 male Aborigines and 57 male Caucasians, macroscopic and microscopic parameters of postnatal cerebellar development were determined and described by mathematic growth functions. For the whole cerebellum and its cortical layers volume measurments revealed delayed maturation for Aborigines compared to Caucasians. Despite the slower development in childhood, significantly smaller values for adult Aborigines compared to Caucasians were observed only for the whole cerebellum and the Purkinje cell sheet. Similarly, postnatal changes in Purkinje cell size showed prolonged growth phases in Aborigines compared to Caucasians. Calculations of absolute cell numbers for individual layers demonstrated later half-value times and slower growth rates for cell numbers in the internal granular and molecular layers consistent with the findings for the corresponding layer volumes. For Caucasians, the growth curve for the absolute cell number in the internal granular layer showed a maximum about 21 months postnatally and subsequently decreased towards adulthood by about 18%. No such overshoot could be demonstrated for Aborigines. In relation to absolute cell numbers in adulthood, this could indicate a smaller number of granule cells migrating from the external to the internal granular layer as well as less pronounced granule cell death in Aborigines compared to Caucasians. The external granular layer of Caucasians increased in volume postnatally to reach a maximum at about 4 months and subsequently decreased until its disappearance at approximately 2 years of age. The number of Purkinje cells decreased marginally postnatally in both populations. These results were discussed in relation to secular changes of growth parameters of the cerebellum during the last century and the socioeconomic and health status of Aborigines.